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Epidemiology and management of chronic thromboembolic pulmonary hypertension.
MedLine Citation:
PMID:  20876914     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare complication of acute pulmonary embolism (PE) with an estimated incidence of 0.5 to 1.5% in the Netherlands, depending on the aetiology of the PE. The underlying pathophysiological mechanism is largely unknown and may be caused by (recurrent) emboli or primarily by a characteristic arteriopathy of the pulmonary arteries. Patients with CTEPH present with nonspecific symptoms predominantly caused by right heart failure and up to 40% have no prior history of venous thromboembolism (VTE). The diagnostic approach of CTE PH aims at assessing the location and extent of the embolic obstruction to establish the operability and prognosis of the patients. A heart catheterisation for invasive pressure measurements is obligatory for the final diagnosis. CTEPH is associated with a poor prognosis if left untreated. The preferred treatment is pulmonary endarterectomy. In certain patients with inoperable disease or with persistent or recurrent pulmonary hypertension after surgery, pharmacotherapy might be beneficial.
Authors:
F A Klok; M V Huisman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Netherlands journal of medicine     Volume:  68     ISSN:  1872-9061     ISO Abbreviation:  Neth J Med     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0356133     Medline TA:  Neth J Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  347-51     Citation Subset:  IM    
Affiliation:
Department of General Internal Medicine-Endocrinology, Section of Vascular Medicine, University Medical Center, Leiden, the Netherlands. F.A.Klok@LUMC.nl
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