Document Detail

Epidemiology, laboratory detection, and therapy of penicillin-resistant streptococcal infections.
MedLine Citation:
PMID:  9635236     Owner:  NLM     Status:  MEDLINE    
Streptococci cause a wide range of infections in humans including respiratory tract infections, endocarditis, meningitis, bacteremias, and skin and soft tissue lesions. Mutations in the penicillin binding proteins target sites in these organisms have recently caused resistance to penicillins and cephalosporins. The passage of resistant genetic material from one streptococcal species to another has been recognized as one of the mechanisms by which this resistance has occurred and spread. Such resistance has been a particular problem in Streptococcus pneumoniae and viridans group streptococci with penicillin resistance levels in excess of 25%, now common in both groups of organisms worldwide. Fourth-generation cephalosporins, with their enhanced antibacterial activity against Gram-positive organisms (cefpirome > cefepime) and their increased stability to the beta-lactamases produced by many bacterial species, offer a new option for the treatment of potentially life-threatening infections such as pneumococcal pneumonia and meningitis with or without bacteremia. Clinical trials are currently in place to evaluate the role of these agents in these, and other, indications of Gram-positive infections. Prior studies of cefpirome therapy for infections caused by Streptococcus spp. were successful, and recent expanded in vitro investigations profess a future for expanded use of cefpirome to treat infections produced by several Gram-positive species.
R N Jones; W R Wilson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Diagnostic microbiology and infectious disease     Volume:  31     ISSN:  0732-8893     ISO Abbreviation:  Diagn. Microbiol. Infect. Dis.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-08-27     Completed Date:  1998-08-27     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8305899     Medline TA:  Diagn Microbiol Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  453-9     Citation Subset:  IM    
Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA.
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MeSH Terms
Anti-Bacterial Agents / pharmacology*
Laboratory Techniques and Procedures
Microbial Sensitivity Tests
Penicillin Resistance*
Streptococcal Infections / drug therapy*,  epidemiology*,  microbiology
Streptococcus / drug effects,  isolation & purification*
United States / epidemiology
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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