| Epidemiology and host- and variety-dependent characteristics of infection due to Cryptococcus neoformans in Australia and New Zealand. Australasian Cryptococcal Study Group. | |
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MedLine Citation:
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PMID: 10987712 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A prospective population-based study was conducted in Australia and New Zealand during 1994-1997 to elucidate the epidemiology of cryptococcosis due to Cryptococcus neoformans var. neoformans (CNVN) and C. neoformans var. gattii (CNVG) and to relate clinical manifestations to host immune status and cryptococcal variety. The mean annual incidence per 10(6) population was 6.6 in Australia and 2.2 in New Zealand. Of 312 episodes, CNVN caused 265 (85%; 98% of the episodes in immunocompromised hosts) and CNVG caused 47 (15%; 44% of the episodes in immunocompetent hosts). The incidence of AIDS-associated cases in Australia declined annually (P<.001). Aborigines in rural or semirural locations (P<.001) and immunocompetent males (P<.001) were at increased risk of CNVG infection. Cryptococcomas in lung or brain were more common in immunocompetent hosts (P< or =.03) in whom there was an association only between lung cryptococcomas and CNVG. An AIDS-associated genetic profile of CNVN serotype A was confirmed by random amplification of polymorphic DNA analysis. Resistance to antifungal drugs was uncommon. The epidemiology of CNVN infection has changed substantially. Clinical manifestations of disease are influenced more strongly by host immune status than by cryptococcal variety. |
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Authors:
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S Chen; T Sorrell; G Nimmo; B Speed; B Currie; D Ellis; D Marriott; T Pfeiffer; D Parr; K Byth |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2000-09-07 |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 31 ISSN: 1058-4838 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 2000 Aug |
Date Detail:
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Created Date: 2000-12-07 Completed Date: 2000-12-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 499-508 Citation Subset: IM |
Affiliation:
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Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, New South Wales, Australia. sharonc@icpmr.wsahs.nsw.gov.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Related Opportunistic Infections
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epidemiology,
microbiology Adolescent Adult Aged Aged, 80 and over Antifungal Agents / pharmacology Australia / epidemiology Child Child, Preschool Cryptococcosis / epidemiology*, immunology, microbiology, physiopathology* Cryptococcus neoformans* / classification, drug effects, genetics, isolation & purification Female Humans Immunocompromised Host Infant Infant, Newborn Male Microbial Sensitivity Tests Middle Aged New Zealand / epidemiology Prospective Studies Random Amplified Polymorphic DNA Technique |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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