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Epidemiology of glomerulonephritis in Northern Germany.
MedLine Citation:
PMID:  21505754     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Knowledge of the exact numbers of patients suffering from chronic diseases, possibly requiring costly continuous treatment, is mandatory for future health care plans. Despite some regional biopsy registries, no valid data about the epidemiology of glomerulonephritis in Germany exist, because all publications are hampered by their retrospective character and lack of completeness. METHODS: In a unique cooperation of out-patient nephrologists with a single major teaching hospital serving a population of approx. 600,000 in the capital of Schwerin and surrounding counties, all patients with abnormal urine findings and/or decreasing renal function of unknown cause were referred for renal biopsy between October 2002 and December 2008. The drop-out rate is assumed to be less than 5%. All biopsies were analysed according to international standards and traditional epidemiological and clinical parameters were collected for comparison with the micro-census of Mecklenburg-Lower Pomerania region of the year 2008. We present the first valid estimations of incidence and 7 year prevalence of glomerulonephritis in Germany. RESULTS: In 222 patients, 251 renal biopsies were performed. The annual biopsy rate was 64 per million population (pmp; range 46.2-87.2). The incidence and prevalence of glomerulonephritis over 7 years was 52 and 285 pmp, respectively. The most frequent glomerulonephritis subtype was mesangioproliferative glomerulonephritis (20.9 pmp) followed by focal and segmental glomerulosclerosis (FSGS, 11.2 pmp) of which 43% had an etiologic underlying condition. The incidences of minimal change nephropathy (MCN), membranous nephropathy and necrotising glomerulonephritis (NGN) were 3.2, 5.2 and 4.9 pmp. In one third of all cases, the glomerulonephritis was secondary (incidence of secondary glomerulonephritis 17.5 pmp). Lupus nephritis and ANCA-associated glomerulonephritis were found in 2.9 and 5.4 cases pmp.
Authors:
Norbert Braun; Anna Schweisfurth; Christine Lohöfener; Catalina Lange; Christian Gründemann; Günther Kundt; Hermann-Josef Gröne
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-20
Journal Detail:
Title:  International urology and nephrology     Volume:  -     ISSN:  1573-2584     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0262521     Medline TA:  Int Urol Nephrol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Internal Medicine, MediClin Müritz-Klinikum, Weinbergstrasse 19, 17192, Waren, Müritz, Germany, norbert.richard.braun@t-online.de.
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