Document Detail


Epidemiology of food allergy/food intolerance in adults: associations with other manifestations of atopy.
MedLine Citation:
PMID:  11736746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Food allergy and food intolerance (FA/FI) are believed to be frequent medical problems; however, information from epidemiologic studies in adults is scarce. The objective was to determine the frequency of FA/FI and allergic sensitization to food in a large adult sample. Furthermore, the associations between FA/FI and other outcomes of atopy were studied. METHODS: Within a population-based, nested, case-control study, a standardized interview was performed to obtain detailed information on FA/FI and the history of atopic diseases. In addition, a skin prick test with 10 common food and nine aeroallergens was performed. RESULTS: Overall, 20.8% of the 1537 studied subjects (50.4% female, age median 50 years) reported FA/FI (women 27.5%, men 14.0%; OR 2.35, CI 1.80-3.08). Nuts, fruits, and milk most frequently led to adverse effects, and the sites of manifestation were oral (42.9%), skin (28.7%), gastrointestinal (13.0%), systemic (3.2%), and multiple (12.2%). One-quarter of the subjects (25.1%) were sensitized to at least one food allergen in the prick test, with hazelnut (17.8%), celery (14.6%), and peanut (11.1%) accounting for most of the positive reactions. The corresponding frequency estimates for the representative study base (n=4178) were 15.5% for reported adverse reactions and 16.8% for allergic sensitization. Relevant concomitant sensitization to food and aeroallergens was observed. Food-allergic subjects (positive history and sensitization to corresponding allergen) suffered significantly more often from urticaria, asthma, atopic eczema, and especially hay fever (73.1%) than controls (3.0%). Furthermore, hay fever was treated significantly more often in subjects who suffered from concomitant food allergy. CONCLUSIONS: FA/FI in adults is frequently reported and associated with other manifestations of atopy. Hay fever in conjunction with FA/FI tends to be clinically more severe since therapeutic needs are enhanced.
Authors:
T Schäfer; E Böhler; S Ruhdorfer; L Weigl; D Wessner; J Heinrich; B Filipiak; H E Wichmann; J Ring
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Allergy     Volume:  56     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-12     Completed Date:  2002-01-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1172-9     Citation Subset:  IM    
Affiliation:
Institute of Social Medicine, Medical University Lübeck, Beckergrube 43047, 23552 Lübeck, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Allergens / adverse effects
Animals
Case-Control Studies
Female
Food Hypersensitivity / epidemiology*,  etiology
Fruit / adverse effects
Germany / epidemiology
Humans
Hypersensitivity, Immediate / epidemiology*,  etiology
Male
Middle Aged
Milk / adverse effects
Nuts / adverse effects
Population Surveillance
Prevalence
Questionnaires
Skin Tests
Chemical
Reg. No./Substance:
0/Allergens
Comments/Corrections
Erratum In:
Allergy 2002 Feb;57(2):178

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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