| Epidemiology of endemic goitre in western Colombia. | |
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MedLine Citation:
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PMID: 80287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper reports on recent epidemiological observations in western Colombia, which further demonstrate the presence of naturally-occurring goitrogens contaminating water supplies in areas where goitre persists despite prolonged and continuous iodine supplementation. 'Prospective' and 'cross-sectional' studies in 41 localities where the populations have been on a uniform and adequate iodine supplementation for the last 10-20 years indicate that, in the endemia of western Colombia, environmental factors other than nutritional iodine deficiency are responsible for differences in goitre prevalence. Further epidemiological studies to determine the causal factors for the persistence of the endemia established a correlation between the sources of drinking water and goitre prevalence rates. Organic compounds containing sulfur with marked thionamide-like antithyroid activity were isolated from water supplying endemic goitre districts, and results are presented supporting the hypothesis that sedimentary rocks rich in organic matter are the main source of water-borne goitrogens. Bacteriological investigations showed that the presence of Klebsiella pneumoniae in drinking water and bacterial concentration were related significantly with goitre prevalence only in the presence of other variables, particularly the presence of sedimentary rocks. In the light of these epidemiological observations and experimental studies it may be concluded that, at present, endemic goitre in western Colombia is not due to nutritional iodine deficiency, but that water supplies are contaminated with sulfur-bearing organic compounds with thionamide-like antithyroid activity most probably deriving from sedimentary rocks rich in organic matter and that these compounds are the main factor underlying the endemia. |
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Authors:
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E Gaitan; H Merino; G Rodriguez; P Medina; J D Meyer; T A DeRouen; R MacLennan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bulletin of the World Health Organization Volume: 56 ISSN: 0042-9686 ISO Abbreviation: Bull. World Health Organ. Publication Date: 1978 |
Date Detail:
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Created Date: 1978-11-18 Completed Date: 1978-11-18 Revised Date: 2010-10-26 |
Medline Journal Info:
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Nlm Unique ID: 7507052 Medline TA: Bull World Health Organ Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 403-16 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antithyroid Agents / adverse effects* Child Colombia Female Geological Phenomena Geology Goiter, Endemic / epidemiology*, etiology, urine Humans Iodine / urine Male Water Supply* |
| Chemical | |
Reg. No./Substance:
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0/Antithyroid Agents; 7553-56-2/Iodine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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