Document Detail

Epidemiology and diagnosis of heart failure with preserved left ventricular ejection fraction: rationale and design of the study.
MedLine Citation:
PMID:  22120964     Owner:  NLM     Status:  MEDLINE    
AIMS: Despite major advances in our understanding of 'systolic' heart failure, at present the epidemiology, pathophysiology, and therapy of heart failure with preserved left ventricular ejection fraction (HFpEF) is poorly understood, in large part because of the lack of robust and widely accepted diagnostic criteria. Although there is a good evidence base for the treatment of systolic heart failure, similar data are lacking for the treatment of HFpEF. Methods In our study, we will screen a consecutive series of 5000 subjects aged ≥60 from the community. Following symptom questionnaire and echocardiography, metabolic exercise testing will be used to confirm whether or not patients thought clinically to have HFpEF are in fact exercise limited and that this limitation is cardiac in origin. Blood samples for plasma brain natriuretic peptide (BNP) will be taken at rest and following exercise in symptomatic patients and matching controls.
CONCLUSIONS: At the end of our study we will establish community prevalence and population characteristics of HFpEF, and also evaluate the diagnostic accuracy of current echocardiography parameters and BNP for the diagnosis of the condition.
Gnanadevan Mahadevan; Girish Dwivedi; Lynne Williams; Richard P Steeds; Michael Frenneaux
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-11-25
Journal Detail:
Title:  European journal of heart failure     Volume:  14     ISSN:  1879-0844     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-19     Completed Date:  2012-05-01     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  106-12     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Echocardiography, Doppler / methods*
Exercise Test / methods*
Great Britain / epidemiology
Heart Failure, Systolic* / diagnosis,  epidemiology,  metabolism,  physiopathology,  therapy
Middle Aged
Natriuretic Peptide, Brain / blood*
Stroke Volume*
Ventricular Dysfunction, Left / physiopathology
Ventricular Function, Left
Grant Support
PG/08/076/25549//British Heart Foundation; PG/09/006/26670//British Heart Foundation
Reg. No./Substance:
114471-18-0/Natriuretic Peptide, Brain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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