Document Detail

Epidemiology and clinical impact of different anatomical phenotypes of the left main coronary artery.
MedLine Citation:
PMID:  20978894     Owner:  NLM     Status:  In-Data-Review    
Several studies have produced estimates of the outcome of percutaneous coronary intervention (PCI) in the field of left main (LM) coronary artery disease, but no research has been found that surveyed the issue of a comprehensive knowledge of LM anatomy and assessed the impact of different anatomic phenotypes on the likelihood of developing complications after LM PCI. We sought to develop a specific investigation on the basis of the regional anatomy and quantitative analysis of a large series of angiograms performed in our institution. We reviewed the baseline selective digital coronary angiographic examinations of 1,000 patients who did not undergo LM PCI and 296 patients with significant LM stenosis who did undergo PCI. All patients in both groups underwent a comprehensive qualitative and quantitative assessment of LM anatomical features according to several parameters. Hierarchical cluster analysis (HCA) was used to identify different anatomic phenotypes of the LM coronary artery. Three different anatomical patterns were identified by HCA. The proportion of patients with LM disease increased across clusters (19% in cluster 1, 27% in cluster 2 and 44% in cluster 3, p < 0.001). No differences were observed in terms of 18-month major adverse cardiac event-free survival among patients with LM disease undergoing PCI stratified by clusters (log rank p = 0.77). In conclusion, LM phenotypes can be identified that are more likely to present with atherosclerotic disease and significant stenosis.
Davide Capodanno; Maria E Di Salvo; Dario Seminara; Anna Caggegi; Giombattista Barrano; Francesco Tagliareni; Fabio Dipasqua; Corrado Tamburino
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Publication Detail:
Type:  Journal Article     Date:  2010-10-27
Journal Detail:
Title:  Heart and vessels     Volume:  26     ISSN:  1615-2573     ISO Abbreviation:  Heart Vessels     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  138-44     Citation Subset:  IM    
Dipartimento di Cardiologia, Ospedale Ferrarotto, Università di Catania, via Citelli 6, 95124, Catania, Italy,
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