| Epidemiology and clinical characteristics of classic Kaposi's sarcoma, seroprevalence, and variants of human herpesvirus 8 in South America: a critical review of an old disease. | |
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MedLine Citation:
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PMID: 16095940 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To review the current South American literature on classic Kaposi's sarcoma (KS) and human herpesvirus 8 (HHV-8), and point the way for studies that still need to be performed. MATERIALS AND METHODS: The authors performed an exhaustive search in LILACS, SCIELO and PUBMED databases for classic KS and HHV-8 in South America. The relevant material was evaluated and reviewed. RESULTS: More than 250 cases have been reported with three big case series (Argentina, Colombia and Peru). The classic KS form seen in Colombia resembles the type of disease seen among African communities; the same unusual presentation with confluent exophytic nodules or eroded lesions has been noticed in Peru. Low rates of HHV-8 antibodies have been found in blood donors from Chile, Argentina and Brazil (3%, 4%, 2.8-7.4%, respectively); whereas high rates of HHV-8 antibodies have been found in Amerindians from Brazil and Ecuador. Five specimens from Argentina were subtyped: (three classic KS and two AIDS KS); the identified strains fell into subtypes A and C. AIDS-related KS specimens from Brazil and Venezuela were subtyped: (43 and nine respectively); analysis grouped them predominantly into subgroups A, B and C. A new HHV-8 subtype E was found endemic in Brazilian and Ecuadorian Amerindians. In French Guiana ten endemic KS and six AIDS-related KS specimens were subtyped; analysis grouped them predominantly into subgroups A, B and C. CONCLUSION: Classic KS in South America has a very similar clinical presentation but not the same as the classic KS variety described in the Mediterranean. Initial seroprevalence studies performed in the general population and in blood donors showed low seroprevalence of HHV-8, whereas high seroprevalence rates were seen in Amerindian population. The existing serological assays, nonetheless, need to be further refined, and new assays need to be developed. Finally, the key to understanding the precise molecular epidemiology and phylogenetic distribution of HHV-8 in South America would be to perform more subtyping of classic KS cases. |
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Authors:
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Salim Mohanna; Vicente Maco; Francisco Bravo; Eduardo Gotuzzo |
Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Volume: 9 ISSN: 1201-9712 ISO Abbreviation: Int. J. Infect. Dis. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-26 Completed Date: 2005-11-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9610933 Medline TA: Int J Infect Dis Country: Canada |
Other Details:
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Languages: eng Pagination: 239-50 Citation Subset: IM |
Affiliation:
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Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru. salim17@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Related Opportunistic Infections
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epidemiology* Adult Aged Aged, 80 and over Antibodies, Viral / blood* Argentina / epidemiology Blood Donors Colombia / epidemiology Female Gastrointestinal Neoplasms / epidemiology* Genome, Viral Hematologic Neoplasms / epidemiology* Herpesviridae Infections / epidemiology* Herpesvirus 8, Human / classification*, immunology* Humans Lung Neoplasms / epidemiology* Male Middle Aged Peru / epidemiology Sarcoma, Kaposi / epidemiology* Seroepidemiologic Studies Skin Neoplasms / epidemiology* South America / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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