| Epidemiology of alternaria alternata allergy: a prospective study in 6840 Italian asthmatic children. | |
| | |
MedLine Citation:
|
PMID: 15745389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The prevalence of Alternaria Alternata (AA), a mold causing in children severe asthma is scarcely known, also due to the underdiagnosis of AA allergy, frequently due to multiple sensitizations to molds. OBJECTIVE: To analyze this issue we prospectively studied all children attending our Division between January 4, 1990 and December 31, 1997. METHODS: A total of 6840 children with asthma or allergic rhinitis were evaluated. Diagnosis was established by family and personal history, physical examination, skin prick tests (SPTs) and RAST (Radio Allergo-Sorbent Test) for inhalants including AA. We further evaluated: (1) sensitization only to AA allergens without positivity for additional inhalants; (2) prevalence of AA positivity among children with asthma or allergic rhinitis; (3) concordance between SPTs and RAST for allergy to molds, (4) proportion of children treated with specific immunotherapy (SIT). RESULTS: Among the 6840 children 213 were positive to AA (3.3%), only 89/6840 children (1.3%) had AA monosensitization (p = 0.0001), a concordance between SPTs and RAST was present in 21/89 (23.6%) children (p = 0.0009), and only 9 children out of 89 were SIT treated. Concerning the clinical manifestations, 83 had asthma or allergic rhinitis, and 6 had asthma associated with atopic dermatitis. Family history was positive in 82.9% of children. The mean onset of AA sensitivity was at age 4 for males, and at age 5 for females. CONCLUSIONS: In childhood, AA allergy is a genetic affection. The SPT concordance with history and clinical examination appears to be operative. Due to life-threatening reactions in children with AA allergy, we suggest that those with suspected inhalant allergy be tested with AA allergens, and treated with SIT if positive. |
| | |
Authors:
|
A Cantani; V Ciaschi |
Related Documents
:
|
8547049 - A protocol for recording the sign of flexural dermatitis in children. 14996099 - Quality of life and disease severity are correlated in children with atopic dermatitis. 11253969 - Sensitisation, asthma, and a modified th2 response in children exposed to cat allergen:... 15274099 - Snoring and atopic disease: a strong association. 1864009 - Serum levels of soluble il-2 receptor, il-4 and ige-binding factors in childhood allerg... 9389289 - Natural rubber latex allergy in children who had not undergone surgery and children who... 19390739 - Tungiasis in schoolchildren in criciúma, santa catarina state, south brazil. 16043399 - Auditory and visual refractory period effects in children and adults: an erp study. 15925419 - The effect of methylphenidate on response inhibition and the event-related potential of... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: European review for medical and pharmacological sciences Volume: 8 ISSN: 1128-3602 ISO Abbreviation: Eur Rev Med Pharmacol Sci Publication Date: 2004 Nov-Dec |
Date Detail:
|
Created Date: 2005-03-04 Completed Date: 2005-04-08 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9717360 Medline TA: Eur Rev Med Pharmacol Sci Country: Italy |
Other Details:
|
Languages: eng Pagination: 289-94 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Allergy and Clinical Immunology Division, University "La Sapienza", Rome, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Allergens / immunology Alternaria / immunology* Asthma / epidemiology, genetics, immunology* Child Child, Preschool Female Humans Infant Italy Male Prospective Studies Rhinitis, Allergic, Perennial / epidemiology*, genetics, immunology Rhinitis, Allergic, Seasonal / epidemiology*, genetics, immunology Skin Tests |
| Chemical | |
Reg. No./Substance:
|
0/Allergens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Does rifaximin prevent complications of diverticular disease? A retrospective study.
Next Document: Gastric emptying time in cyclic vomiting syndrome in children.