| Epidemiology of the adverse hemodynamic events occurring during "clonidine anesthesia": a prospective open trial of intraoperative intravenous clonidine. | |
| | |
MedLine Citation:
|
PMID: 7576677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
STUDY OBJECTIVE: Determine the hemodynamic consequences of intraoperative clonidine during major abdominal surgery. DESIGN: Prospective open trial. SETTING: Teaching hospital. PATIENTS: 402 consecutive patients scheduled for major abdominal surgery. INTERVENTIONS: 350 consecutive patients received intravenous (IV) clonidine (loading dose of 4 micrograms/kg in 20 minutes at anesthesia induction, followed by a continuous infusion of 2 micrograms/kg/h until the end of surgery). Fifty-two additional patients served as controls. Anesthetic technique consisted of balanced anesthesia (isoflurane, fentanyl, atracurium). ECG, invasive arterial blood pressure (BP), expiratory PCO2 and pulse oximetry were continuously recorded. Hemodynamic events (HEs) were defined as moderate for a 20% reduction of the baseline systolic blood pressure (SBP) or a heart rate (HR) decreasing between 50 beats per minute (bpm) and 40 bpm. A 30% reduction of the baseline SBP or a HR below 40 bpm was considered an important HE. The rate and duration of these events were recorded from induction to recovery. HEs requiring a specific treatment were noted. Central venous pressure, volume of fluid infused, and urinary output were also recorded. MEASUREMENTS AND MAIN RESULTS: 21% of control patients and 31% of clonidine patients had no adverse HEs. A moderate reduction of the baseline BP was the most common episode in both groups. The incidence of the HEs (moderate and important) was similar in both groups but the duration HEs was significantly longer in the clonidine patients (p < 0.05). 40% of the control patients and 13% of the clonidine patients required specific management for their HEs (p < 0.05), the most common of which was hypotension without bradycardia. Neither coexisting pathology nor preoperative medications influenced the incidence of HEs. CONCLUSION: IV clonidine can be used routinely during anesthesia for major abdominal surgery. |
| | |
Authors:
|
M De Kock; H Versailles; B Colinet; R Karthaeuser; J L Scholtes |
Related Documents
:
|
2137627 - Actions of beta-endorphin and related peptide fragments on a pressor response induced b... 6463077 - The effects of clonidine, prazosin, and propranolol on short-term and long-term habitua... 3913757 - Cardiovascular and hormonal effects of clonidine in patients with essential hypertensio... 6317467 - Effect of antihypertensive therapy on sympathetic nervous system activity in patients w... 22085017 - Assessment of the ex vivo biomechanical properties of porcine cornea with inflation tes... 20927117 - Role of the nitric oxide metabolic pathway and prostanoids in the pathogenesis of endot... |
Publication Detail:
|
Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
|
Title: Journal of clinical anesthesia Volume: 7 ISSN: 0952-8180 ISO Abbreviation: J Clin Anesth Publication Date: 1995 Aug |
Date Detail:
|
Created Date: 1995-12-15 Completed Date: 1995-12-15 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8812166 Medline TA: J Clin Anesth Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 403-10 Citation Subset: IM |
Affiliation:
|
Department of Anesthesiology, University of Louvain Medical School, St. Luc Hospital, Brussels, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abdomen
/
surgery Adrenergic alpha-Agonists / administration & dosage, adverse effects* Anesthesia, Inhalation Anesthesia, Intravenous* Anesthetics, Intravenous / administration & dosage, adverse effects* Antihypertensive Agents / administration & dosage, adverse effects* Blood Pressure / drug effects* Carbon Dioxide / analysis Central Venous Pressure / drug effects Clonidine / administration & dosage, adverse effects* Electrocardiography Female Fluid Therapy Heart Rate / drug effects* Humans Hypotension / chemically induced Incidence Infusions, Intravenous Intraoperative Care* Male Middle Aged Oximetry Prospective Studies Respiration Urine |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic alpha-Agonists; 0/Anesthetics, Intravenous; 0/Antihypertensive Agents; 124-38-9/Carbon Dioxide; 4205-90-7/Clonidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of sevoflurane and halothane anesthesia in children undergoing outpatient ear, nose, and ...
Next Document: Hemodynamic comparison of direct vision versus blind oral endotracheal intubation.