Document Detail


Epidemiology of Respiratory Syncytial Virus Infection in Infants Born at Less Than 35 Weeks of Gestational Age.
MedLine Citation:
PMID:  22531234     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: The aims of this study were to observe the respiratory syncytial virus (RSV) hospitalization rate and to identify the risk factors for hospitalization for RSV infection among infants in Korea born at less than 35 weeks of gestational age and who had not previously received palivizumab. METHODS: We conducted a study over a 2.5-year period (April 2007-September 2009) that included premature infants (<35 weeks of gestational age) who underwent follow-up during the year after discharge from the neonatal intensive care unit (NICU). Demographic information was collected for each subject at baseline, and the reasons for hospitalization were obtained during the 1-year follow-up period. RESULTS: The study population included 1022 subjects who completed follow-up interviews. Eight hundred seventeen infants were included in analysis for RSV hospitalization. Excluded from the study were 167 subjects with chronic lung disease who had received palivizumab prophylaxis and 38 subjects who were not tested for RSV. The overall incidence of RSV hospitalization in the group that did not receive palivizumab was 4.5% (37 of 817 patients). Independent risk factors associated with RSV hospitalization were multiple gestation (P=0.022) and longer duration of mechanical ventilation in the NICU (P=0.039). CONCLUSION: This study showed the epidemiology and risk factors of RSV hospitalization in preterm infants in Korea. RSV infection was one of the main causes of hospitalization after discharge from the NICU in patients born at less than 35 weeks of gestational age.
Authors:
Hye Won Park; Byong Sop Lee; Ai-Rhan Kim; Hye Sun Yoon; Beyong Il Kim; Eun Song Song; Woo Taek Kim; Jaewoo Lim; Seungyeon Kim; Hyun-Seung Jin; Shinyun Byun; Dong Hyun Chee; Ki-Soo Kim
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-23
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  -     ISSN:  1532-0987     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Department of Pediatrics, Division of Neonatology, Konkuk University Hospital, Konkuk University School of Medicine 2University of Ulsan, College of Medicine, Children's Hospital, Asan Medical Center 3Eulji University, College of Medicine, Eulji Hospital, Seoul 4Seoul National University, Bundang Hospital, Seongnam 5Chonnam National University Hospital, Gwangju 6Daegu Catholic University Medical Center, Daegu 7Konyang University Hospital 8Eulji University, College of Medicine, Eulji Hospital, Daejon 9University of Ulsan, College of Medicine, GangNeung Asan Hospital, Gangwon-do 10Pusan National University Children's Hospital, Yangsan 11Abbott Korea Limited, Seoul, Korea.
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