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Epidemiology of Orofacial clefts in Africa: Methodological challenges in ascertainment.
MedLine Citation:
PMID:  21532901     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: To carry out a systematic review of the birth prevalence of cleft lip with or without cleft palate (CLP) and cleft palate (CP) in Africa based on available published data.
METHOD: Using the Cochrane search strategy and the following keywords words "cleft palate", "prevalence", "incidence", "cleft lip" and "Africa" to screen Ovid Medline {1966 to March 2007), Cinahl {1982-March 2007}, Pub Med, Scopus, and Web-Google. All identified published, prospective and retrospective studies on the birth prevalence of CLP and CP in Africa were included. The dates, location, sources, number of births (live births, still births, number of cleft cases, prevalence rates, sex ratio, cleft types, and clefts with associated anomalies were extracted.
RESULTS: Ascertainment of cases was through the hospitals. Overall there were 57 CL/P, 56 CL and 36 CP reported from all the studies. From seven studies combined, 21 males and 20 females had CL, 10 males and 22 females with CP and 26 males and 24 females with CL/P. There were 3 cases with CL/P, 2 with CP and 2 with CL from the three studies that reported clefts with associated anomalies.
CONCLUSION: For an improved ascertainment of cleft cases, there is a need to set up a birth defects surveillance system in the form of a national birth registry. Future studies should then aim to include the entire population in geographically defined regions. Reliable data on incidence is an essential pre-requisite for studies into aetiology and prevention.
Authors:
A Butali; P A Mossey
Publication Detail:
Type:  Journal Article     Date:  2009-04-30
Journal Detail:
Title:  The Pan African medical journal     Volume:  2     ISSN:  1937-8688     ISO Abbreviation:  Pan Afr Med J     Publication Date:  2009  
Date Detail:
Created Date:  2011-05-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101517926     Medline TA:  Pan Afr Med J     Country:  Uganda    
Other Details:
Languages:  eng     Pagination:  5     Citation Subset:  -    
Affiliation:
PhD candidate.
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