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Epidemiology of Keratoconus in an Iranian Population.
MedLine Citation:
PMID:  22710491     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE:: To determine the incidence of clinical keratoconus (KCN) in an Iranian population. METHODS:: This prospective surveillance study was conducted in Yazd province in central Iran (population 990,818). During 1 year (July 2008 to June 2009), all new patients with KCN were registered and referred. Diagnosis was based on the topographic pattern, and indices were measured and eye examination was done by anterior segment subspecialists. RESULTS:: Of the 564 eligible patients referred, 28 did not attend their topography session (95% response rate). Topographic figures showed suspect or definite patterns of KCN in 47.8% of participants (256/536 subjects). Based on topographic images and clinical examination, KCN was confirmed in 221 patients, and in addition, 26 patients were categorized as having suspected KCN and 9 had non-KCN corneal diseases; therefore, the annual incidence rate of KCN was estimated as 22.3 (95% confidence interval, 19.5-25.4) and 24.9 (95% confidence interval, 21.9-28.2) per 100,000 population, excluding and including suspected KCN cases, respectively. CONCLUSION:: The incidence of KCN in our context is apparent and comparable with rates in other studies on Asian ethnic populations. This is much higher than the incidence in European Caucasians and warrants further genetic and environmental studies.
Authors:
Hossein Ziaei; Mohammad Reza Jafarinasab; Mohammad Ali Javadi; Farid Karimian; Hossein Poorsalman; Manijeh Mahdavi; Mohammad Reza Shoja; Marzieh Katibeh
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-15
Journal Detail:
Title:  Cornea     Volume:  -     ISSN:  1536-4798     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8216186     Medline TA:  Cornea     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
*Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran †Department of Ophthalmology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
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