Document Detail

[Epidemiology of Bone and Joint Disease - The Present and Future - . Epidemiology of osteoporosis and osteoporotic fracture in Japan].
MedLine Citation:
PMID:  24769675     Owner:  NLM     Status:  In-Data-Review    
Osteoporosis is a major burden on modern society because of its high prevalence and tragic consequences due to fractures. According to population-based epidemiologic studies, number of people with osteoporosis in Japan was estimated to be 13 million in 2005, and only 20% of them were under treatment. Osteoporosis is a highly undertreated disease. Number of hip fractures occurred in Japan in 2007 was approximately 130 thousands which were 2.8-fold greater than those in 1987. This increase can be explained by an increase in the elderly population. Prevalence rate of vertebral fracture was reported to be approximately 30% in women aged 70s and 40% in those aged 80s. Fracture risk assessment in individuals is essential for osteoporosis management. To improve prediction accuracy for major osteoporotic fractures, FRAX® model including clinical risk factors was developed. Predicted risk of major osteoporotic fractures for Japanese women by FRAX® were not significantly different from observed risk in the Japanese Population-based Osteoporosis (JPOS) Cohort Study, and FRAX® model without bone mineral density (BMD) showed a similar validity to FRAX® model with BMD. This suggests that FRAX® without BMD may be used as a screening tool for people at increased risk of fractures in community. However, FRAX® should be improved further in combination with new bone strength indices. Epidemiology should play a great role in developing and evaluating such improvement in fracture risk assessment.
Masayuki Iki
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Clinical calcium     Volume:  24     ISSN:  0917-5857     ISO Abbreviation:  Clin Calcium     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-04-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433326     Medline TA:  Clin Calcium     Country:  Japan    
Other Details:
Languages:  jpn     Pagination:  657-64     Citation Subset:  IM    
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