Document Detail

Epidemiology of apnea and bradycardia resolution in premature infants.
MedLine Citation:
PMID:  21746726     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There is little epidemiologic evidence to assess the maturation of respiratory control in premature infants.
OBJECTIVE: To measure the success rate or the percentage of infants who have no additional events of various apnea- or bradycardia-free intervals after correcting for gestational age, postmenstrual age of the last apnea or bradycardia event, and the severity of the event.
METHODS: This was a retrospective cohort study of infants born at 34 weeks' gestational age or earlier at 1 of 5 Kaiser Permanente Medical Care Program hospitals between 1998 and 2001. The success rates of various apnea- or bradycardia-free intervals were calculated after stratifying according to gestational age, postmenstrual age of the last event, or event severity.
RESULTS: Among the 1403 infants identified in this study, 84.2% did not have an apnea event and 78.5% did not have a bradycardia event after they were otherwise ready for discharge. For the entire cohort, a 95% success rate was statistically reached, with a 7-day apnea- or bradycardia-free interval. Infants with a gestational age of 30 weeks or less had a 5% to 15% lower success rate than infants with a gestational age more than 30 weeks for any given apnea- or bradycardia-free interval. The success rate was reduced by an additional 5% to 10% if the last apnea or bradycardia event occurred at a postmenstrual age of more than 36 weeks. Including only the most severe events slightly improved the success rate of a given interval.
CONCLUSIONS: The risk of recurrence for apnea or bradycardia differs depending on the gestational age of the infant and the postmenstrual age of the last apnea or bradycardia event.
Scott A Lorch; Lakshmi Srinivasan; Gabriel J Escobar
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2011-07-11
Journal Detail:
Title:  Pediatrics     Volume:  128     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-02     Completed Date:  2011-10-13     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e366-73     Citation Subset:  AIM; IM    
Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
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MeSH Terms
Age Factors
Apnea / epidemiology*,  etiology,  physiopathology
Bradycardia / epidemiology*,  etiology,  physiopathology
Cohort Studies
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / epidemiology*,  etiology,  physiopathology
Retrospective Studies
Risk Factors
Grant Support
R40 MC00236//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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