Document Detail

Epidemiological study of lower limb amputation in England between 2003 and 2008.
MedLine Citation:
PMID:  20632310     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The purpose of this study was to investigate the prevalence of lower extremity amputation in England, to establish the associated mortality, and to determine the relationship with diabetes mellitus and previous revascularization. METHODS: Data on all patients who had a lower extremity amputation between 2003 and 2008 were extracted from the Hospital Episode Statistics database. Risk adjustment and linear regression were used to compare the data. RESULTS: The major amputation rate was 5.1 per 100,000 population and did not change over the 5 years. The mortality rate for major leg amputation was 16.8 per cent (21.4 per cent for above-knee and 11.6 per cent for below-knee amputation); this decreased significantly over time (P < 0.001). There was a significant difference in amputation rate, mortality rate and the below-knee : above-knee amputation ratio between different areas of England (P < 0.001). Some 39.4 per cent of patients who underwent major amputation had diabetes mellitus. The odds of revascularization before amputation increased significantly over time (P = 0.035). CONCLUSION: Major and minor amputation rates were stable across England between 2003 and 2008, accompanied by a significant reduction in perioperative mortality. There were significant geographical variations in amputation rates, mortality rates and the below-knee : above-knee amputation ratio.
P W Moxey; D Hofman; R J Hinchliffe; K Jones; M M Thompson; P J E Holt
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of surgery     Volume:  97     ISSN:  1365-2168     ISO Abbreviation:  Br J Surg     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-04     Completed Date:  2010-09-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  1348-53     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Department of Outcomes Research, St George's Vascular Institute, St George's Healthcare NHS Trust, London, UK.
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MeSH Terms
Amputation / mortality,  statistics & numerical data*
Blood Vessel Prosthesis Implantation / mortality,  statistics & numerical data
Diabetic Angiopathies / mortality,  surgery
England / epidemiology
Foot / surgery*
Hospital Mortality
Leg / surgery*
Risk Adjustment

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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