| Epidemiological evidence on reproductive effects of persistent organochlorines in humans. | |
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MedLine Citation:
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PMID: 15336708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Organochlorines are widespread pollutants in humans. Concern about adverse reproductive effects of these compounds arises from accidental exposure of humans and experimental studies. Recently, this issue has been addressed by a number of studies of exposed populations and hospital-based case-referent studies. These studies indicate that high concentrations of persistent organochlorines may adversely affect semen quality and cause testicular cancer in males, induce menstrual cycle abnormalities and spontaneous abortions in females, and cause prolonged waiting time pregnancy, reduced birth weight, skewed sex ratio, and altered age of sexual development. However, most effects have been demonstrated at exposure levels above the present day exposure level in European and North American populations. Due to inherent methodological problems in several of the available studies, additional research is needed to fully elucidate the possible adverse effects of organochlorines on human reproductive health. |
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Authors:
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Gunnar Toft; Lars Hagmar; Alexander Giwercman; Jens Peter Bonde |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Reproductive toxicology (Elmsford, N.Y.) Volume: 19 ISSN: 0890-6238 ISO Abbreviation: Reprod. Toxicol. Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-08-31 Completed Date: 2005-04-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8803591 Medline TA: Reprod Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 5-26 Citation Subset: IM |
Affiliation:
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Department of Occupational Medicine, Aarhus University Hospital, Noerrebrogade 44, Build. 2C, 8000 Aarhus C, Denmark. gutof@akh.aaa.dk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Environmental Pollutants / toxicity* Europe / epidemiology Female Genital Diseases, Female / chemically induced*, epidemiology, pathology Genital Diseases, Male / chemically induced*, epidemiology, pathology Hormone Antagonists / toxicity Humans Hydrocarbons, Chlorinated / toxicity* Male North America / epidemiology Pregnancy Reproduction / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Environmental Pollutants; 0/Hormone Antagonists; 0/Hydrocarbons, Chlorinated |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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