Document Detail

Epidemiological evidence on reproductive effects of persistent organochlorines in humans.
MedLine Citation:
PMID:  15336708     Owner:  NLM     Status:  MEDLINE    
Organochlorines are widespread pollutants in humans. Concern about adverse reproductive effects of these compounds arises from accidental exposure of humans and experimental studies. Recently, this issue has been addressed by a number of studies of exposed populations and hospital-based case-referent studies. These studies indicate that high concentrations of persistent organochlorines may adversely affect semen quality and cause testicular cancer in males, induce menstrual cycle abnormalities and spontaneous abortions in females, and cause prolonged waiting time pregnancy, reduced birth weight, skewed sex ratio, and altered age of sexual development. However, most effects have been demonstrated at exposure levels above the present day exposure level in European and North American populations. Due to inherent methodological problems in several of the available studies, additional research is needed to fully elucidate the possible adverse effects of organochlorines on human reproductive health.
Gunnar Toft; Lars Hagmar; Alexander Giwercman; Jens Peter Bonde
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  19     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-08-31     Completed Date:  2005-04-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5-26     Citation Subset:  IM    
Department of Occupational Medicine, Aarhus University Hospital, Noerrebrogade 44, Build. 2C, 8000 Aarhus C, Denmark.
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MeSH Terms
Environmental Pollutants / toxicity*
Europe / epidemiology
Genital Diseases, Female / chemically induced*,  epidemiology,  pathology
Genital Diseases, Male / chemically induced*,  epidemiology,  pathology
Hormone Antagonists / toxicity
Hydrocarbons, Chlorinated / toxicity*
North America / epidemiology
Reproduction / drug effects*
Reg. No./Substance:
0/Environmental Pollutants; 0/Hormone Antagonists; 0/Hydrocarbons, Chlorinated

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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