Document Detail


Epidemiological evidence against a role for C-reactive protein causing leptin resistance.
MedLine Citation:
PMID:  23047304     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: It has been suggested that elevated levels of C-reactive protein (CRP) might interfere with leptin signalling and contribute to leptin resistance. Our aim was to assess whether plasma levels of CRP influence leptin resistance in humans, and our hypothesis was that CRP levels would modify the cross-sectional relationships between leptin and measures of adiposity.
DESIGN AND METHODS: W assessed four measures of adiposity: BMI, waist circumference, fat mass and body fat (%) in 2113 British Regional Heart Study (BRHS) men (mean (s.d.) age 69 (5) years), with replication in 760 (age 69 (6) years) European Male Ageing Study (EMAS) subjects.
RESULTS: IN BRHS subjects, leptin correlated with CRP (SPEARMAN'S R=0.22, P0.0001). Leptin and crp correlated with all four measures of adiposity (R VALUE RANGE: 0.22-0.57, all P<0.0001). Age-adjusted mean levels for adiposity measures increased in relation to leptin levels, but CRP level did not consistently influence the β-coefficients of the regression lines in a CRP-stratified analysis. In BRHS subjects, the BMI vs leptin relationship demonstrated a weak statistical interaction with CRP (P=0.04). We observed no similar interaction in EMAS subjects and no significant interactions with other measures of adiposity in BRHS or EMAS cohorts.
CONCLUSION: We have shown that plasma CRP has little influence on the relationship between measures of adiposity and serum leptin levels in these middle-aged and elderly male European cohorts. This study provides epidemiological evidence against CRP having a significant role in causing leptin resistance.
Authors:
M K Rutter; N Sattar; A Tajar; T W O'Neill; D M Lee; G Bartfai; S Boonen; F F Casanueva; J D Finn; G Forti; A Giwercman; T S Han; I T Huhtaniemi; K Kula; M E J Lean; N Pendleton; M Punab; A J Silman; D Vanderschueren; G Lowe; S O'Rahilly; R W Morris; F C Wu; S G Wannamethee;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2012-12-10
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  168     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-02-04     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  101-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / anatomy & histology
Adiposity
Adult
Aged
Body Mass Index
C-Reactive Protein / metabolism*
Cohort Studies
Drug Resistance
Humans
Leptin / blood*
Male
Middle Aged
Waist Circumference
Grant Support
ID/Acronym/Agency:
G0900554//Medical Research Council; G1001375//Medical Research Council; G9824984//Medical Research Council
Chemical
Reg. No./Substance:
0/Leptin; 9007-41-4/C-Reactive Protein
Investigator
Investigator/Affiliation:
G Forti / ; Luisa Petrone / ; Antonio Cilotti / ; D Vanderschueren / ; S Boonen / ; Herman Borghs / ; K Kula / ; Jolanta Slowikowska-Hilczer / ; Renata Walczak-Jedrzejowska / ; I T Huhtaniemi / ; A Giwercman / ; F C Wu / ; A J Silman / ; N Pendleton / ; T W O'Neill / ; J D Finn / ; Philip Steer / ; A Tajar / ; D M Lee / ; Stephen Pye / ; F F Casanueva / ; Mary Lage / ; G Bartfai / ; Imre Foldesi / ; Imre Fejes / ; M Punab / ; Paul Korrovitz / ; Min Jiang /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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