| Epidemiological and clinical features of hepatitis B virus related liver failure in China. | |
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MedLine Citation:
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PMID: 21799653 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To examine the epidemiologic and clinical characteristics of hepatitis B virus (HBV) related liver failure in patients in China. METHODS: This study was conducted with a retrospective design to examine 1066 patients with HBV-related liver failure in the southwest of China. RESULTS: There were more male than female patients. Young and middle-aged people comprised most of the patients. Farmers and laborers comprised the largest proportion (63.09%). Han Chinese accounted for 98.12%, while minority ethnic groups only accounted for 0.88% of patients. A total of 43.47% patients had a family history of HBV-related liver failure and 56.66% patients had a history of drinking alcohol. A total of 42.59% patients with HBV-related liver failure had definite causes. With regard to the clinical manifestation of HBV-related liver failure, the symptoms were: hypodynamia, anorexia and abdominal distension. Total bilirubin (TBIL) and alanine aminotransferase (ALT) levels were altered in 46.23% of patients with evident damage of the liver. Univariate logistic regression analysis showed that the patients' prognoses were correlated with ALT, aspartate aminotransferase, albumin, TBIL, prothrombin activity (PTA), and alpha-fetoprotein levels, and drinking alcohol, ascites, hepatorenal syndrome, infection and ≥ 2 complications. Multifactor logistic regression analysis showed that the activity of thrombinogen and the number of complications were related to the prognosis. CONCLUSION: Alcohol influences the patients' prognosis and condition. PTA and complications are independent factors that can be used for estimating the prognosis of HBV-related liver failure. |
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Authors:
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Chen Liu; Yu-Ming Wang; Ke Fan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 17 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-29 Completed Date: 2011-10-31 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 3054-9 Citation Subset: IM |
Affiliation:
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Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alcohol Drinking / adverse effects China / epidemiology Female Hepatitis B virus / pathogenicity* Hepatitis B, Chronic / complications, epidemiology*, virology* Humans Liver Failure / diagnosis, epidemiology*, etiology, virology* Male Middle Aged Prognosis Retrospective Studies Young Adult |
| Comments/Corrections | |
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