Document Detail


Epidemiological and clinical features of hepatitis B virus related liver failure in China.
MedLine Citation:
PMID:  21799653     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To examine the epidemiologic and clinical characteristics of hepatitis B virus (HBV) related liver failure in patients in China.
METHODS: This study was conducted with a retrospective design to examine 1066 patients with HBV-related liver failure in the southwest of China.
RESULTS: There were more male than female patients. Young and middle-aged people comprised most of the patients. Farmers and laborers comprised the largest proportion (63.09%). Han Chinese accounted for 98.12%, while minority ethnic groups only accounted for 0.88% of patients. A total of 43.47% patients had a family history of HBV-related liver failure and 56.66% patients had a history of drinking alcohol. A total of 42.59% patients with HBV-related liver failure had definite causes. With regard to the clinical manifestation of HBV-related liver failure, the symptoms were: hypodynamia, anorexia and abdominal distension. Total bilirubin (TBIL) and alanine aminotransferase (ALT) levels were altered in 46.23% of patients with evident damage of the liver. Univariate logistic regression analysis showed that the patients' prognoses were correlated with ALT, aspartate aminotransferase, albumin, TBIL, prothrombin activity (PTA), and alpha-fetoprotein levels, and drinking alcohol, ascites, hepatorenal syndrome, infection and ≥ 2 complications. Multifactor logistic regression analysis showed that the activity of thrombinogen and the number of complications were related to the prognosis.
CONCLUSION: Alcohol influences the patients' prognosis and condition. PTA and complications are independent factors that can be used for estimating the prognosis of HBV-related liver failure.
Authors:
Chen Liu; Yu-Ming Wang; Ke Fan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  17     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-29     Completed Date:  2011-10-31     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  3054-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Drinking / adverse effects
China / epidemiology
Female
Hepatitis B virus / pathogenicity*
Hepatitis B, Chronic / complications,  epidemiology*,  virology*
Humans
Liver Failure / diagnosis,  epidemiology*,  etiology,  virology*
Male
Middle Aged
Prognosis
Retrospective Studies
Young Adult
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