Document Detail

Epidemiological and clinical consequences of within-host evolution.
MedLine Citation:
PMID:  21055948     Owner:  NLM     Status:  In-Process    
Many viruses and bacteria are known to evolve rapidly over the course of an infection. However, epidemiological studies generally assume that within-host evolution is an instantaneous process. We argue that the dynamics of within-host evolution has implications at the within-host and at the between-host levels. We first show that epidemiologists should consider within-host evolution, notably because it affects the genotype of the pathogen that is transmitted. We then present studies that investigate evolution at the within-host level and examine the extent to which these studies can help to understand infection traits involved in the epidemiology (e.g. transmission rate, virulence, recovery rate). Finally, we discuss how new techniques for data acquisition can open new perspectives for empirical and theoretical research.
Samuel Alizon; Fabio Luciani; Roland R Regoes
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Publication Detail:
Type:  Journal Article     Date:  2010-11-04
Journal Detail:
Title:  Trends in microbiology     Volume:  19     ISSN:  1878-4380     ISO Abbreviation:  Trends Microbiol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9310916     Medline TA:  Trends Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  24-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Laboratoire Génétique et Évolution des Maladies Infectieuses, Unité Mixte de Recherche du Centre national de la Recherche Scientifique et de l'Institut de Recherche pour le Développement 2724, 911 avenue Agropolis, BP 64501, 34394 Montpellier CEDEX 5, France.
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