Document Detail

Epidemiological appraisal of the literature on the fetal alcohol syndrome in humans.
MedLine Citation:
PMID:  7026219     Owner:  NLM     Status:  MEDLINE    
An evaluation of the evidence regarding the association between heavy maternal alcohol intake during pregnancy and the occurrence in offspring of that cluster of abnormalities called the Fetal Alcohol Syndrome is undertaken from an epidemiological perspective. Areas of concern in assessing the literature include the objectivity with which the maternal drinking history was obtained, the nature, systematic or not, of examination of offspring, the presence or absence of a comparison group, the control for potentially confounding factors and, perhaps most important of all, whether or not the identification of a case was made blind to knowledge of the maternal drinking history. While well-documented evidence that can implicate a hypothesized teratogen is difficult to obtain, the data available concerning the effects of in utero exposure to high doses of alcohol must be carefully and thoughtfully scrutinized so that valid inferences may be drawn. In this review particular attention is focused on the nature of the association between in utero alcohol exposure and mental retardation, certainly the most devastating of the FAS features.
R H Neugut
Related Documents :
18000129 - Systematic review of the fetal effects of prenatal binge-drinking.
1576219 - Potential sources of bias and confounding in environmental epidemiologic studies of pre...
2911419 - Cocaine abuse during pregnancy: maternal and fetal implications.
795609 - Local treatment of psoriasis of the scalp with clobetasol propionate and betamethasone-...
24111719 - Macrophage infiltration and stress-signaling in omental and subcutaneous adipose tissue...
16020199 - Effect of in vivo jet fuel exposure on subsequent in vitro dermal absorption of individ...
1653089 - Amount of urinary iodine excretion in residents of taipei city--a hospital-based study.
16522429 - Steady-state levels of aquaporin 1 mrna expression are increased in idiopathic polyhydr...
15292309 - Impact of ovarian hyperstimulation on thyroid function in women with and without thyroi...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Early human development     Volume:  5     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1981-12-21     Completed Date:  1981-12-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  411-29     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Abnormalities, Drug-Induced / etiology
Epidemiologic Methods
Face / abnormalities
Fetal Alcohol Syndrome / epidemiology*
Maternal-Fetal Exchange
Mental Retardation / chemically induced
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Update on the treatment of bacterial urinary tract infections.
Next Document:  Localization of renin in trophoblasts in human chorion laeve at term pregnancy.