Document Detail

Epidemiological MIC cut-off values for tigecycline calculated from Etest MIC values using normalized resistance interpretation.
MedLine Citation:
PMID:  16410264     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To apply the normalized resistance interpretation (NRI) method to Etest MIC results which have higher precision than conventional log2 dilution MIC tests due to the inclusion of intermediate values. If successful, NRI might provide an objective tool for the definition of epidemiological MIC cut-off values. METHODS: MICs of tigecycline and other antimicrobial agents were determined for 4771 clinical isolates comprising five Gram-positive and 13 Gram-negative species or species groups using the Etest. Histograms of MIC values were constructed for each species and NRI calculations were applied to them. An upper MIC limit of 2.5 SD above the theoretical mean of the normalized distribution was used for setting the epidemiological cut-off values. RESULTS: Calculated cut-off values for wild-type strains were between 0.11 and 0.96 mg/L for Gram-positive species, and between 0.44 and 8.3 mg/L for Gram-negative species, except for Pseudomonas aeruginosa, which had a cut-off value of 450 mg/L, consistent with earlier reports on the lack of activity of tigecycline against this species. CONCLUSIONS: NRI offers an objective method for the analysis of MICs produced using Etests and the determination of epidemiological MIC cut-off values.
Göran Kronvall; Inga Karlsson; Mats Walder; Mikael Sörberg; Lennart E Nilsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-12
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  57     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-07     Completed Date:  2006-05-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  England    
Other Details:
Languages:  eng     Pagination:  498-505     Citation Subset:  IM    
Clinical Microbiology--MTC, Karolinska Institute, Karolinska Hospital L2:02, 17176 Stockholm, Sweden.
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MeSH Terms
Anti-Bacterial Agents / pharmacology*
Drug Resistance, Bacterial*
Epidemiologic Methods
Gram-Negative Bacteria / drug effects
Gram-Positive Bacteria / drug effects
Microbial Sensitivity Tests
Minocycline / analogs & derivatives*,  pharmacology
Models, Biological
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/tigecycline; 10118-90-8/Minocycline

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