Document Detail

Epidemiologic evidence that prior antimicrobial exposure decreases resistance to infection by antimicrobial-sensitive Salmonella.
MedLine Citation:
PMID:  2299207     Owner:  NLM     Status:  MEDLINE    
Exposure to antimicrobials is known to increase the risk of infection with antimicrobial-resistant strains of Salmonella, but this effect has not been previously demonstrated with antimicrobial-sensitive strains. The effect of prior antimicrobial exposure was studied during a multistate outbreak of salmonellosis caused by an antimicrobial-sensitive strain of Salmonella havana: 19 (26%) of 72 persons infected had taken an antimicrobial within 30 days before onset of symptoms. Antimicrobial therapy was begun a mean of 15.9 days before and stopped a mean of 7.9 days before onset. In a case-control study, 11 (31%) of 35 case-patients had taken antimicrobials within 30 days of onset compared with 9 (13%) of 70 age- and neighborhood-matched controls (matched odds ratio, 4.3; 95% confidence interval, 1.3, 13.5). The association remained when controlled for the presence of underlying illness or immunosuppression. Prior antimicrobial exposure appears to increase the risk of infection with antimicrobial-sensitive and resistant strains of Salmonella. The delay between antimicrobial use and onset of symptoms suggests that the effect may be due to prolonged alteration of the colonic bacterial flora, resulting in decreased resistance to colonization.
A T Pavia; L D Shipman; J G Wells; N D Puhr; J D Smith; T W McKinley; R V Tauxe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  161     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-03-09     Completed Date:  1990-03-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  255-60     Citation Subset:  AIM; IM    
Enteric Diseases Branch, Centers for Disease Control, Atlanta, GA 30333.
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MeSH Terms
Aged, 80 and over
Anti-Bacterial Agents / pharmacology*,  therapeutic use
Case-Control Studies
Child, Preschool
Disease Outbreaks*
Drug Resistance, Microbial
Georgia / epidemiology
Immune Tolerance
Middle Aged
Pregnancy Complications, Infectious / drug therapy,  epidemiology,  microbiology
Salmonella / drug effects*
Salmonella Food Poisoning / etiology
Salmonella Infections / drug therapy*,  epidemiology,  microbiology
United States / epidemiology
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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