Document Detail

Epidemiologic evidence supporting the role of maternal vitamin D deficiency as a risk factor for the development of infantile autism.
MedLine Citation:
PMID:  20592795     Owner:  NLM     Status:  PubMed-not-MEDLINE    
This study examines whether maternal vitamin D deficiency is a risk factor for infantile autism disease (IAD). We used epidemiologic data seasonal variation of birth rates and prevalence of IAD for cohorts born before 1985. For seven studies reporting spring-to-summer excess birth rates for IAD, the season progressed from broad near 30 degrees N latitude, spring/summer in midlatitudes, to winter at the highest latitude. Also, using data from 10 studies, we found a strong effective latitudinal (related to wintertime solar ultraviolet B radiation) increase in IAD prevalence. These findings are consistent with maternal vitamin D deficiency's being a risk factor for IAD, possibly by affecting fetal brain development as well as possibly by affecting maternal immune system status during pregnancy. Further investigation of this hypothesis is warranted.
William B Grant; Connie M Soles
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Dermato-endocrinology     Volume:  1     ISSN:  1938-1980     ISO Abbreviation:  Dermatoendocrinol     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2010-07-01     Completed Date:  2011-07-14     Revised Date:  2014-10-09    
Medline Journal Info:
Nlm Unique ID:  101495367     Medline TA:  Dermatoendocrinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  223-8     Citation Subset:  -    
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Erratum In:
Dermatoendocrinol. 2009 Nov;1(6):314

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