| Epidemiologic correlates of ovarian cortical inclusion cysts (CICs) support a dual precursor pathway to pelvic epithelial cancer. | |
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MedLine Citation:
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PMID: 19615727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Many ovarian carcinomas are presumed to arise within ovarian cortical inclusion cysts (CICs). This study examined the frequency of ovarian CICs in relation to epidemiologic risk factors in women with BRCA1 and BRCA2 (BRCA+) mutations. METHODS: BRCA+ women who underwent risk-reducing bilateral salpingo-oophorectomy were studied (n=74). Fifteen demographic variables (e.g., age at time of surgery, age at first birth, age at menopause, body mass index (BMI), gravidity) from a review of the medical records and three pathologic variables (cystic and atretic follicles, corpora lutea) were recorded. Statistical associations were made using T-test or Chi Square analysis and logistic regression analysis for p-trend. RESULTS: Women whose ovaries contained 7 for more CICs were older at first birth (p=0.034), surgery (p=0.059), menopause (p=0.046) and had a higher BMI (p=0.034) than those with <7 CICs. Regression analysis revealed a significant association between CICs and increasing BMI (p=0.01). CONCLUSIONS: CICs correlate with greater body mass index, similar to low-grade serous and endometrioid tumors and in contrast to high-grade serous carcinoma and its putative precursor in the fallopian tube. A model is presented for ovarian and tubal pathways to pelvic cancer that are linked to different microscopic precursors with distinct epidemiologic correlates. |
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Authors:
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Ann K Folkins; Aasia Saleemuddin; Leslie A Garrett; Judy E Garber; Michael G Muto; Shelley S Tworoger; Christopher P Crum |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-07-16 |
Journal Detail:
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Title: Gynecologic oncology Volume: 115 ISSN: 1095-6859 ISO Abbreviation: Gynecol. Oncol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-08-31 Completed Date: 2009-09-07 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0365304 Medline TA: Gynecol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 108-11 Citation Subset: IM |
Affiliation:
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Divisionsof Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carcinoma, Endometrioid / epidemiology, genetics Fallopian Tube Neoplasms / epidemiology, genetics Female Genes, BRCA1 Genes, BRCA2 Genes, p53 Genetic Predisposition to Disease Humans Mutation Ovarian Cysts / epidemiology*, genetics Ovarian Neoplasms / epidemiology, genetics Ovariectomy Pelvic Neoplasms / epidemiology*, genetics Risk Factors Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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1R21CA124688-01A1/CA/NCI NIH HHS; P50 CA105009-01/CA/NCI NIH HHS; P50CA10500/CA/NCI NIH HHS; R21 CA124688-02/CA/NCI NIH HHS |
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