Document Detail

Epidemiologic approaches for studying recurrent pregnancy outcomes: challenges and implications for research.
MedLine Citation:
PMID:  17531901     Owner:  NLM     Status:  MEDLINE    
The study of recurrence of pregnancy-related complications and outcomes can offer powerful insights to understanding patient-related risks for subsequent pregnancies. Such studies, when designed, analyzed, and interpreted correctly, can help distinguish genetic from environmental causes that portend increased recurrence of a particular pregnancy complication (eg, recurrence of gestational diabetes) or a perinatal outcome (eg, recurrence of preterm birth or preeclampsia). Recurrence risk studies can be challenging in other dimensions, including inherent biases, generalizability of findings, inadequate study size, and inappropriate use of analytic models to study recurrence. Other common misperceptions in studies of recurrence risk are highlighted, including issues with terminology and interpretation of recurrence risks. A review of available epidemiologic study designs is presented and the usefulness and applicability of each design for addressing specific etiologic questions as they relate to recurrence risks are contrasted.
Cande V Ananth
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Seminars in perinatology     Volume:  31     ISSN:  0146-0005     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-28     Completed Date:  2007-07-24     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  196-201     Citation Subset:  IM    
Division of Epidemiology and Biostatistics, Department of Obstetrics, Gynecology, and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ 08901-1977, USA.
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MeSH Terms
Epidemiologic Studies
Pregnancy Complications / epidemiology*,  etiology,  prevention & control*
Pregnancy Outcome
Research Design
Grant Support

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