| Epidemics with multistrain interactions: the interplay between cross immunity and antibody-dependent enhancement. | |
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MedLine Citation:
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PMID: 20059219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper examines the interplay of the effect of cross immunity and antibody-dependent enhancement (ADE) in multistrain diseases. Motivated by dengue fever, we study a model for the spreading of epidemics in a population with multistrain interactions mediated by both partial temporary cross immunity and ADE. Although ADE models have previously been observed to cause chaotic outbreaks, we show analytically that weak cross immunity has a stabilizing effect on the system. That is, the onset of disease fluctuations requires a larger value of ADE with small cross immunity than without. However, strong cross immunity is shown numerically to cause oscillations and chaotic outbreaks even for low values of ADE. |
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Authors:
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Simone Bianco; Leah B Shaw; Ira B Schwartz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Chaos (Woodbury, N.Y.) Volume: 19 ISSN: 1089-7682 ISO Abbreviation: Chaos Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-01-11 Completed Date: 2010-03-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100971574 Medline TA: Chaos Country: United States |
Other Details:
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Languages: eng Pagination: 043123 Citation Subset: IM |
Affiliation:
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Department of Applied Science, The College of William and Mary, Williamsburg, Virginia 23187, USA. sbianco@wm.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibody-Dependent Enhancement / immunology* Communicable Diseases / epidemiology*, immunology* Computer Simulation Disease Outbreaks / statistics & numerical data Disease Transmission, Infectious / statistics & numerical data* Humans Immunity, Innate / immunology* Models, Immunological* Nonlinear Dynamics* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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