Document Detail


Epidemic meticillin-resistant Staphylococcus aureus (EMRSA-15) variants detected in healthy and diseased individuals in India.
MedLine Citation:
PMID:  20339016     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study provides what we believe to be the first report of the presence of EMRSA-15 and its variants isolated from nasal swabs from 13 healthy and diseased individuals in India. The majority of the isolates belonged to staphylococcal cassette chromosome mec (SCCmec) type IV and spa type t852, whilst four isolates were non-typable and heterotypic for the presence of the mecA gene. All non-typable isolates were positive for the orfX gene by PCR and belonged to spa types t005 and t2986. They may have variant SCCmec cassettes indicating genetic changes occurring in the Indian EMRSA-15. All isolates were positive for Panton-Valentine leukocidin and toxic shock syndrome toxin, which is a cause for concern. In addition to soft-tissue infections, the EMRSA-15 isolates from patients were also responsible for meningitis and brain abscesses, which is quite rare.
Authors:
Savitha Nadig; Shilpa Ramachandra Raju; Gayathri Arakere
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-25
Journal Detail:
Title:  Journal of medical microbiology     Volume:  59     ISSN:  1473-5644     ISO Abbreviation:  J. Med. Microbiol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-18     Completed Date:  2010-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0224131     Medline TA:  J Med Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  815-21     Citation Subset:  IM    
Affiliation:
Sir Dorabji Tata Centre for Research in Tropical Diseases, Innovation Centre, Indian Institute of Science Campus, Bangalore 560012, India.
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Disease Outbreaks
Genetic Variation
Humans
India / epidemiology
Methicillin-Resistant Staphylococcus aureus / classification,  genetics,  isolation & purification*
Staphylococcal Infections / epidemiology*,  microbiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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