Document Detail

Epidemic of haemorrhagic disease in Vietnamese infants caused by warfarin-contaminated talcs.
MedLine Citation:
PMID:  6130257     Owner:  NLM     Status:  MEDLINE    
In August, 1981, paediatric hospitals in Ho Chi Minh City (formerly Saigon), Vietnam, began to report cases of a haemorrhagic syndrome in infants. The cause of this haemorrhagic phenomenon was identified as talcum powder contaminated with the anticoagulant warfarin. Analysis of talcum powders revealed warfarin in concentrations between 1.7% and 6.5%. 741 cases were detected and 177 patients died. The possibility of accidental contamination or substitution of a perfuming agent by warfarin can be rejected. In an experiment with two baboons, the animal exposed to the contaminated talc died five days later from haemorrhage. The accident and the animal study demonstrate the significant transcutaneous uptake of the anticoagulant.
G Martin-Bouyer; N B Khanh; P D Linh; D Q Hoa; L C Tuan; J Tourneau; C Barin; H Guerbois; T V Binh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  230-2     Citation Subset:  AIM; IM    
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MeSH Terms
Disease Outbreaks / epidemiology
Drug Contamination
Hemorrhagic Disorders / chemically induced*
Infant, Newborn
Maternal-Fetal Exchange
Pan troglodytes
Skin / metabolism
Skin Absorption
Talc / administration & dosage,  adverse effects*
Warfarin / adverse effects*,  metabolism
Reg. No./Substance:
14807-96-6/Talc; 81-81-2/Warfarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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