| Epidemic of haemorrhagic disease in Vietnamese infants caused by warfarin-contaminated talcs. | |
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MedLine Citation:
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PMID: 6130257 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In August, 1981, paediatric hospitals in Ho Chi Minh City (formerly Saigon), Vietnam, began to report cases of a haemorrhagic syndrome in infants. The cause of this haemorrhagic phenomenon was identified as talcum powder contaminated with the anticoagulant warfarin. Analysis of talcum powders revealed warfarin in concentrations between 1.7% and 6.5%. 741 cases were detected and 177 patients died. The possibility of accidental contamination or substitution of a perfuming agent by warfarin can be rejected. In an experiment with two baboons, the animal exposed to the contaminated talc died five days later from haemorrhage. The accident and the animal study demonstrate the significant transcutaneous uptake of the anticoagulant. |
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Authors:
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G Martin-Bouyer; N B Khanh; P D Linh; D Q Hoa; L C Tuan; J Tourneau; C Barin; H Guerbois; T V Binh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Lancet Volume: 1 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1983 Jan |
Date Detail:
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Created Date: 1983-03-11 Completed Date: 1983-03-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 230-2 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Outbreaks / epidemiology Drug Contamination Female Hemorrhagic Disorders / chemically induced* Humans Infant Infant, Newborn Male Maternal-Fetal Exchange Pan troglodytes Pregnancy Skin / metabolism Skin Absorption Syndrome Talc / administration & dosage, adverse effects* Vietnam Warfarin / adverse effects*, metabolism |
| Chemical | |
Reg. No./Substance:
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14807-96-6/Talc; 81-81-2/Warfarin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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