Document Detail


Epicardium Formation as a Sensor in Toxicology.
MedLine Citation:
PMID:  25232532     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Zebrafish (Danio rerio) are an excellent vertebrate model for studying heart development, regeneration and cardiotoxicity. Zebrafish embryos exposed during the temporal window of epicardium development to the aryl hydrocarbon receptor (AHR) agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exhibit severe heart malformations. TCDD exposure prevents both proepicardial organ (PE) and epicardium development. Exposure later in development, after the epicardium has formed, does not produce cardiac toxicity. It is not until the adult zebrafish heart is stimulated to regenerate does TCDD again cause detrimental effects. TCDD exposure prior to ventricular resection prevents cardiac regeneration. It is likely that TCDD-induced inhibition of epicardium development and cardiac regeneration occur via a common mechanism. Here, we describe experiments that focus on the epicardium as a target and sensor of zebrafish heart toxicity.
Authors:
Peter Hofsteen; Jessica Plavicki; Richard E Peterson; Warren Heideman
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Journal of developmental biology     Volume:  1     ISSN:  2221-3759     ISO Abbreviation:  J Dev Biol     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2014-9-18     Completed Date:  -     Revised Date:  2014-9-24    
Medline Journal Info:
Nlm Unique ID:  101613409     Medline TA:  J Dev Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  112-125     Citation Subset:  -    
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 ES012716/ES/NIEHS NIH HHS

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