Document Detail

Epicardial radiofrequency ablation on a beating heart: an experimental study.
MedLine Citation:
PMID:  15788964     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The effect of epicardial radiofrequency ablation (RFA) during normal heart beating was experimentally studied in order to establish safe and effective procedures for RFA. METHODS: Seven pigs weighing approximately 30 to 50 kg were used in this study. Fifty-one epicardial RFA lesions were created on both atria using a Cobra Cooled probe with continuous internal irrigation of a saline solution. The ablation temperature was fixed at 80 degrees C and the duration of the RFA in each case was 20, 30, 60 and 120 seconds. RESULTS: There was significant positive correlation between the right and left atria in wall thickness. Transmural coagulation was obtained in 69% of the total specimens, which decreased according to the increase of wall thickness especially over 3 mm. Transmural coagulation was seen in 64% of the specimens after RFA of less than 30 seconds, and 86% after ablation of >or=60 seconds. Occurence of 90% or deeper coagulation was higher in the right atrium than in the left one (97% vs. 78%). Right atrial rupture occurred in a region of 1 mm in thickness after ablation of 60 seconds. CONCLUSION: Further technical improvements associated with new instruments are indispensable to complete epicardial RFA procedures on a beating heart.
Susumu Ishikawa; Shigeru Oki; Masato Muraoka; Kiyohiro Oshima; Kenji Kashiwabara; Yasuo Morishita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia     Volume:  11     ISSN:  1341-1098     ISO Abbreviation:  Ann Thorac Cardiovasc Surg     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-03-24     Completed Date:  2005-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9703158     Medline TA:  Ann Thorac Cardiovasc Surg     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  21-4     Citation Subset:  IM    
Second Department of Surgery, Gunma University Graduate School of Medicine, Gunma, Japan.
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MeSH Terms
Catheter Ablation / methods*
Heart Atria / pathology,  physiopathology,  surgery
Myocardial Contraction / physiology
Pericardium / pathology,  physiopathology,  surgery*
Saline Solution, Hypertonic / administration & dosage
Time Factors
Reg. No./Substance:
0/Saline Solution, Hypertonic

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