Document Detail


Epicardial progenitor cells in cardiac regeneration and neovascularisation.
MedLine Citation:
PMID:  22902355     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
While cardiovascular diseases remain the major worldwide cause of mortality and morbidity, there is an urgent need to tackle the clinical and economic burden of heart failure. Since the mammalian heart is unable to adequately regenerate beyond early postnatal stages, individuals surviving acute myocardial infarction are at risk of heart failure. Understanding the embryonic mechanisms of vasculogenesis and cardiogenesis, as well as the mechanisms retained for regeneration in species such as the zebrafish, will inform on strategies for human myocardial repair. Due to their fundamental role in heart development, epicardium-derived cells (EPDCs) have emerged as a population with potential to restore myocardium and coronary vasculature. The ability to revive ordinarily dormant EPDCs lies in the identification of key molecular cues used in the embryo to orchestrate cardiovascular development. One such stimulatory factor, Thymosin β4 (Tβ4), restores the quiescent adult epicardium to its pluripotent embryonic state. Tβ4 treatment of infarcted hearts induces dramatic EPDC proliferation and formation of a network of perfused, functional vessels to enhance blood flow to the ischaemic myocardium. Moreover, Tβ4 facilitates an epicardial contribution of mature de novo cardiomyocytes, structurally and functionally coupled with resident myocardium, which may contribute towards the functional improvement of Tβ4-treated hearts post-MI.
Authors:
Nicola Smart; Karina N Dubé; Paul R Riley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-11
Journal Detail:
Title:  Vascular pharmacology     Volume:  58     ISSN:  1879-3649     ISO Abbreviation:  Vascul. Pharmacol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-22     Completed Date:  2013-09-13     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101130615     Medline TA:  Vascul Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  164-73     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Cell Proliferation
Heart Failure / physiopathology,  therapy*
Humans
Myocardial Infarction / physiopathology
Myocardium / pathology
Myocytes, Cardiac / metabolism
Neovascularization, Physiologic / physiology
Pericardium / cytology
Regeneration
Stem Cells / metabolism*
Thymosin / metabolism*
Grant Support
ID/Acronym/Agency:
FS/08/004/23625//British Heart Foundation; //British Heart Foundation
Chemical
Reg. No./Substance:
61512-21-8/Thymosin; 77591-33-4/thymosin beta(4)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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