Document Detail


Epicardial maps of atrial fibrillation after linear ablation lesions.
MedLine Citation:
PMID:  9300302     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: The purpose of this study was to investigate the mechanisms by which atrial linear ablation lesions eliminate atrial fibrillation (AF). METHODS AND RESULTS: With an array of 112 unipole, epicardial maps of electrically induced AF in 6 dogs (acute group), self-sustained AF in 6 dogs (chronic group), and sinus rhythm and atrial pacing in 3 dogs (control group) were analyzed before and after creating linear radiofrequency ablation lesions in both atria that eliminated the AF. In the acute and chronic groups, activation maps showed multiple wavelets with complex patterns of activation and reentry during AF. Conduction velocity and the number, size, and complexity of wavelets did not change, whereas median fibrillatory cycle length increased with the number of linear lesions. In the control group, refractoriness and conduction velocity were unaffected by the number of lesions. CONCLUSIONS: In these models of AF, linear lesions that eliminate AF increase the cycle length of AF without changing conduction velocity, number of size of wavelets, or complexity of activation patterns.
Authors:
H J Sih; E J Berbari; D P Zipes
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  8     ISSN:  1045-3873     ISO Abbreviation:  J. Cardiovasc. Electrophysiol.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-11-04     Completed Date:  1997-11-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1046-54     Citation Subset:  IM    
Affiliation:
Department of Medicine, Krannert Institute of Cardiology, Indianapolis, IN 46202-4800, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Atrial Fibrillation / physiopathology*
Body Surface Potential Mapping
Cardiac Pacing, Artificial
Catheter Ablation / methods*
Dogs
Heart Conduction System / physiopathology
Pericardium / physiopathology*
Time Factors
Grant Support
ID/Acronym/Agency:
HL52323/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
J Cardiovasc Electrophysiol. 1998 Jan;9(1):112-3   [PMID:  9475587 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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