Document Detail


Epicardial gene therapy and laser revascularization.
MedLine Citation:
PMID:  10980864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite the proven effectiveness of coronary bypass surgery and percutaneous angioplasty techniques, an increasing number of patients are presenting with severe, medically intractable angina who are not candidates for either procedure. Two alternative strategies, transmyocardial laser revascularization and exogeneous administration of angiogenic growth factors (therapeutic angiogenesis) are currently being evaluated in such patients. This review focuses on the current status of these two procedures, emphasizing their similarities and differences in order to provide insight into what role each may ultimately play in the management of patients with otherwise unrevascularizable myocardial ischemia.
Authors:
J F Symes
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current cardiology reports     Volume:  1     ISSN:  1523-3782     ISO Abbreviation:  Curr Cardiol Rep     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-12-14     Completed Date:  2000-12-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100888969     Medline TA:  Curr Cardiol Rep     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  335-43     Citation Subset:  IM    
Affiliation:
St. Elizabeth's Medical Center, 11 Nevins Street, Boston, MA 02135, USA.
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Animals
Combined Modality Therapy
Coronary Disease / surgery,  therapy*
Cost-Benefit Analysis
Endothelial Growth Factors / therapeutic use*
Fibroblast Growth Factors / therapeutic use
Gene Therapy*
Humans
Laser Therapy / methods*
Lymphokines / therapeutic use*
Myocardial Revascularization / methods*
Pericardium / surgery
Transfection
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Chemical
Reg. No./Substance:
0/Endothelial Growth Factors; 0/Lymphokines; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors; 62031-54-3/Fibroblast Growth Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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