| Epicardial coronary artery Doppler: validation in the animal model. | |
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MedLine Citation:
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PMID: 18487235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the study was to validate a newly-designed epicardial coronary artery Doppler probe and test its detection of changes in coronary blood flow velocity. Left anterior descending (LAD) coronary blood flow and flow velocity were evaluated in four pigs with a pericoronary transit time flow (TTF) probe and a newly-designed epicardial Doppler micro-probe. Four consecutive measurements were taken for each of the following conditions: basal, partial stenosis, occlusion, and reperfusion of the LAD. Mean TTF value (ml/min) was 23.2+/-6.6 in basal condition, 16.2+/-5.7 after partial LAD stenosis, 0.1+/-0.3 during LAD occlusion, and 67.4+/-23.3 at reperfusion (P<0.001). Similar patterns were recorded in terms of Doppler velocity (cm/s) with values of 4.0+/-1.9 in basal condition, 3.5+/-2.3 after partial LAD stenosis, 0.5+/-1.4 during LAD occlusion, and 11.1+/-5.5 at reperfusion (P<0.001). No significant differences in both TTF and Doppler velocity were detected between basal condition and partial LAD stenosis (P=ns). Epicardial coronary arterial Doppler represents a valuable tool to detect coronary arterial flow velocity in basal condition. Although changes in flow velocity are easily recorded after coronary occlusion and reperfusion, modifications after partial coronary stenosis are not clearly defined. |
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Authors:
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Giuseppe D'Ancona; Joost M Hartman; Fabio Bartolozzi; Elza van Deel; Dirk J G M Duncker; Ad J J C Bogers; Michele Pilato; Arie P Kappetein |
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Publication Detail:
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Type: Comparative Study; Journal Article; Validation Studies Date: 2008-05-16 |
Journal Detail:
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Title: Interactive cardiovascular and thoracic surgery Volume: 7 ISSN: 1569-9285 ISO Abbreviation: Interact Cardiovasc Thorac Surg Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-30 Completed Date: 2008-10-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101158399 Medline TA: Interact Cardiovasc Thorac Surg Country: England |
Other Details:
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Languages: eng Pagination: 634-7 Citation Subset: IM |
Affiliation:
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Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands. rgea@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity Coronary Circulation* Coronary Occlusion / physiopathology, ultrasonography* Coronary Stenosis / physiopathology, ultrasonography* Coronary Vessels / physiopathology, ultrasonography* Disease Models, Animal Echocardiography, Doppler* / instrumentation Equipment Design Laser-Doppler Flowmetry* / instrumentation Pericardium Reproducibility of Results Swine Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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