Document Detail

Epicardial conductors can lower the defibrillation threshold in rabbit hearts.
MedLine Citation:
PMID:  19272936     Owner:  NLM     Status:  MEDLINE    
During a defibrillation shock, epicardial conductors can introduce antistimulatory effects due to lowering of the voltage gradient in myocardial tissue under the conductor and stimulatory effects due to membrane polarization near edges. We hypothesized that increasing the area of conductors increases the defibrillation threshold (DFT), while increasing the amount of stimulatory edge of conductors decreases the DFT. To test this, we measured the DFT in excised rabbit hearts with and without sets of rectangular conductors having 250 or 500 mm(2) area and 100, 200, or 400 mm length of edges perpendicular to the line intersecting the shock electrodes. Unlike previous reports in which conductors increased or did not change DFT, present results indicate a conductor geometry having area of 250 mm (2) and edge of 200 mm decreases the DFT. This result is consistent with the hypothesis that stimulatory effects of the edge of a conductor can enhance defibrillation shock efficacy.
Jared A Sims; Stephen B Knisley Ast
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; In Vitro; Journal Article; Research Support, N.I.H., Extramural     Date:  2008-10-21
Journal Detail:
Title:  IEEE transactions on bio-medical engineering     Volume:  56     ISSN:  1558-2531     ISO Abbreviation:  IEEE Trans Biomed Eng     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-08     Completed Date:  2009-07-24     Revised Date:  2011-07-26    
Medline Journal Info:
Nlm Unique ID:  0012737     Medline TA:  IEEE Trans Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1196-9     Citation Subset:  IM    
Department of Biomedical Engineering, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
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MeSH Terms
Analysis of Variance
Differential Threshold
Electric Conductivity
Electric Countershock / instrumentation*,  methods
Electric Stimulation / instrumentation
Pericardium / physiology*
Grant Support
5T32HL069768-04/HL/NHLBI NIH HHS; HL52003/HL/NHLBI NIH HHS; HL67728/HL/NHLBI NIH HHS; R01 HL052003-05/HL/NHLBI NIH HHS; R01 HL067728-05/HL/NHLBI NIH HHS; T32 HL069768-01/HL/NHLBI NIH HHS; T32 HL069768-06/HL/NHLBI NIH HHS

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