Document Detail


Ephs and ephrins keep pancreatic Beta cells connected.
MedLine Citation:
PMID:  17448984     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
How insulin-secreting beta cells of the pancreas communicate with each other is largely unknown. In this issue of Cell, Konstantinova et al. (2007) show that the signaling proteins EphA and ephrin-A modulate insulin secretion, providing fresh insights into the functional significance of the clustering of beta cells, which occurs in islets.
Authors:
Rohit N Kulkarni; C Ronald Kahn
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Cell     Volume:  129     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-23     Completed Date:  2007-06-04     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  241-3     Citation Subset:  IM    
Affiliation:
Division of Cell and Molecular Physiology, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston MA 02215, USA. rohit.kulkarni@joslin.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Ephrins / metabolism*
Glucose / metabolism
Humans
Insulin / secretion
Insulin-Secreting Cells / metabolism*,  secretion
Pancreas / cytology,  metabolism
Receptors, Eph Family / metabolism*
Chemical
Reg. No./Substance:
0/Ephrins; 11061-68-0/Insulin; 50-99-7/Glucose; EC 2.7.10.1/Receptors, Eph Family
Comments/Corrections
Comment On:
Cell. 2007 Apr 20;129(2):359-70   [PMID:  17448994 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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