| EphrinB3 regulates cell proliferation and survival in adult neurogenesis. | |
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MedLine Citation:
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PMID: 16483793 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interactions between ephrins and their receptors have been implicated in many processes during central nervous system development. In the adult, ephrins and Eph receptors have been implicated in controlling cell proliferation and neuroblast migration, although there is no direct evidence for the role of ephrinB3 in these functions. In addition, activation of Eph receptors has been shown to regulate transduction pathways important in cell cycle control as well as cell death. We show that ephrinB3 contributes to the control of cell proliferation and survival in the adult subventricular zone (SVZ). EphrinB3(-/-) mice exhibit a significant increase in dividing cells along the lateral ventricle, and altered expression of proteins involved in cell cycle regulation. Gain-of-function approach by infusing soluble ephrinB3-Fc molecules in ephrinB3(-/-) can suppress cell proliferation to wild type levels. At the same time, ephrinB3 also regulates cell survival as greater numbers of cells die in the SVZ of ephrinB3(-/-) mice. Together, our results suggest that ephrinB3 negatively regulates cell cycle progression and cell apoptosis in the adult subventricular zone. |
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Authors:
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Jerome Ricard; Jessica Salinas; Lissette Garcia; Daniel J Liebl |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-02-17 |
Journal Detail:
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Title: Molecular and cellular neurosciences Volume: 31 ISSN: 1044-7431 ISO Abbreviation: Mol. Cell. Neurosci. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-04-03 Completed Date: 2006-11-22 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9100095 Medline TA: Mol Cell Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 713-22 Citation Subset: IM |
Affiliation:
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The Miami Project to Cure Paralysis and Department of Neurosurgery, University of Miami School of Medicine, 1095 NW 14th Terrace, R-48, Miami, FL 33136, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Brain / anatomy & histology, metabolism Cell Proliferation* Cell Survival* Ephrin-B1 / metabolism Ephrin-B2 / metabolism Ephrin-B3 / genetics, metabolism* Humans Mice Mice, Knockout Nerve Tissue Proteins Neurons / cytology, physiology* Receptors, Eph Family / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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NS049545/NS/NINDS NIH HHS; NS30291/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ephrin-B1; 0/Ephrin-B2; 0/Ephrin-B3; 0/Nerve Tissue Proteins; 0/neurogenesin-1 protein, rat; EC 2.7.10.1/Receptors, Eph Family |
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