| Ephedrine plus caffeine causes age-dependent cardiovascular responses in Fischer 344 rats. | |
| | |
MedLine Citation:
|
PMID: 15653753 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Human consumption of ephedrine and caffeine in dietary supplements has been associated with a number of adverse effects including changes in the ECG, myocardial infarction, hyperthermia, and, in rare instances, death. The purpose of this study was to investigate the potential mechanisms associated with the cardiotoxicity of combined ephedrine and caffeine ingestion. Seven- and fourteen-week-old Fischer 344 rats treated with ephedrine in combination with caffeine exhibited increases in heart rate (HR), temperature, and corrected QT interval. Of the 14-wk-old rats treated with 25 mg/kg ephedrine plus 30 mg/kg caffeine, 57% died within 3-5 h of treatment, whereas none of the similarly treated 7-wk-old rats nor any of the rats treated with vehicle died. One hour after treatment with this dose of ephedrine plus caffeine, 14-wk-old rats exhibited a larger increase in HR (as % increase over baseline) than 7-wk-old rats. Furthermore, the 14-wk-old rats that died had a higher HR and temperature than the 14-wk-old rats that lived. Histopathological studies suggested interstitial hemorrhage and myofiber necrosis in the 14-wk-old rats treated with the highest concentration of ephedrine and caffeine. This study showed enhanced susceptibility to ephedrine plus caffeine in 14-wk-old rats compared with 7-wk-old rats. The greater mortality in the 14-wk-old rats was associated with increases in body temperature, HR, and myocardial necrosis. |
| | |
Authors:
|
Reuben Howden; Paul R Hanlon; John G Petranka; Steven Kleeberger; John Bucher; June Dunnick; Abraham Nyska; Elizabeth Murphy |
Related Documents
:
|
10639903 - Thermoregulatory responses to acute heat loads in the fok rat. 10898753 - Mechanism of the alcohol cyclic pattern: role of the hypothalamic-pituitary-thyroid axis. 3135123 - Comparison of the effects of carbon tetrachloride and of 2,3,7,8-tetrachlorodibenzo-p-d... |
Publication Detail:
|
Type: In Vitro; Journal Article Date: 2005-01-14 |
Journal Detail:
|
Title: American journal of physiology. Heart and circulatory physiology Volume: 288 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2005 May |
Date Detail:
|
Created Date: 2005-04-20 Completed Date: 2005-05-31 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: H2219-24 Citation Subset: IM |
Affiliation:
|
Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Animals Body Temperature / drug effects Caffeine / toxicity* Central Nervous System Stimulants / toxicity* Drug Synergism Electrocardiography / drug effects Ephedrine / toxicity* Fever / chemically induced*, mortality, pathology Heart Rate / drug effects* Male Papillary Muscles / drug effects, pathology Rats Rats, Inbred F344 |
| Chemical | |
Reg. No./Substance:
|
0/Central Nervous System Stimulants; 299-42-3/Ephedrine; 58-08-2/Caffeine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: K+ currents regulate the resting membrane potential, proliferation, and contractile responses in ven...
Next Document: Defective calcium handling in cardiomyocytes isolated from hearts subjected to ischemia-reperfusion.