Document Detail

Ephedrine-induced increases in arterial blood pressure accelerate regression of epidural block.
MedLine Citation:
PMID:  7573997     Owner:  NLM     Status:  MEDLINE    
We investigated the hypothesis that ephedrine-induced increases in blood pressure accelerate the regression of epidural block. In patients undergoing minor gynecologic surgery, we performed lumbar epidural blockade using 2% lidocaine containing 1:200,000 epinephrine to which was added 0.1 mg of fentanyl. Eighty minutes after the epidural injection, we started an ephedrine infusion to increase the systolic blood pressure by 20% in 10 min and maintained the value for the following 20 min. Then we compared the proximal extent of sensory analgesia at 80 min with that at 140 min. Ephedrine significantly (P = 0.001) hastened the regression of sensory analgesia. We conclude that an ephedrine-induced blood pressure increase accelerates regression of epidural blockade.
W Ueda; Y Kataoka; E Takimoto; M K Tomoda; J Aono; Y Sagara; M Manabe
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  81     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1995-11-06     Completed Date:  1995-11-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  703-5     Citation Subset:  AIM; IM    
Department of Anesthesiology, Kochi Medical School, Japan.
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MeSH Terms
Adjuvants, Anesthesia
Anesthesia, Epidural*
Anesthetics, Local
Blood Pressure / drug effects*
Ephedrine / pharmacology*
Heart Rate / drug effects
Middle Aged
Pain Measurement
Time Factors
Reg. No./Substance:
0/Adjuvants, Anesthesia; 0/Anesthetics, Local; 137-58-6/Lidocaine; 299-42-3/Ephedrine; 437-38-7/Fentanyl; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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