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Ephedrine accelerates psychomotor recovery from anesthesia in macaque monkeys.
MedLine Citation:
PMID:  22594699     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background  Ephedrine is used in treatment of hypotension during anesthesia. We investigated its effects on the psychomotor recovery and its potential adverse reactions on cardiorespiratory functions in rhesus monkeys. Methods  The monkeys received 50 μg/kg medetomidine, 2.0 mg/kg S-ketamine with 150 IU hyaluronidase i.m. Pulse rate, blood pressure and saturation of haemoglobin were monitored for 20 minutes. Thereafter, 1 mg/kg of ephedrine or a placebo was administered i.m. and behavioural changes, pulse rate, blood pressure and saturation of haemoglobin were monitored every 5 minutes. Results  Ephedrine shortened recovery from anaesthesia from 80.4 ± 25.8 to 14.83 ± 13.70 minutes. Ephedrine also increased oxygen saturation of haemoglobin and systolic blood pressure and caused significant decrease in pulse rate 5 minutes after its administration. Conclusions  Ephedrine can be successfully used to accelerate psychomotor recovery after the use of common anesthetic protocols combining dissociative anesthetic agent and alpha 2-adrenoceptor agonist in primates.
Authors:
L Hess; M Votava; J Slíva; J Málek; A Kurzová; K Stein
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-18
Journal Detail:
Title:  Journal of medical primatology     Volume:  -     ISSN:  1600-0684     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0320626     Medline TA:  J Med Primatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
 Laboratory of Experimental Anaesthesiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic  Department of Pharmacology, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic  Department of Pharmacology, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic  Department of Anaesthesiology and Critical Care Medicine, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic  Military Health Insurance Company, Prague, Czech Republic.
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