Document Detail


EphB signaling controls lineage plasticity of adult neural stem cell niche cells.
MedLine Citation:
PMID:  21112567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stem cells remain in specialized niches over the lifespan of the organism in many organs to ensure tissue homeostasis and enable regeneration. How the niche is maintained is not understood, but is probably as important as intrinsic stem cell self-renewal capacity for tissue integrity. We here demonstrate a high degree of phenotypic plasticity of the two main niche cell types, ependymal cells and astrocytes, in the neurogenic lateral ventricle walls in the adult mouse brain. In response to a lesion, astrocytes give rise to ependymal cells and ependymal cells give rise to niche astrocytes. We identify EphB2 forward signaling as a key pathway regulating niche cell plasticity. EphB2 acts downstream of Notch and is required for the maintenance of ependymal cell characteristics, thereby inhibiting the transition from ependymal cell to astrocyte. Our results show that niche cell identity is actively maintained and that niche cells retain a high level of plasticity.
Authors:
Tadashi Nomura; Christian Göritz; Timothy Catchpole; Mark Henkemeyer; Jonas Frisén
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell stem cell     Volume:  7     ISSN:  1875-9777     ISO Abbreviation:  Cell Stem Cell     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-29     Completed Date:  2011-03-18     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  101311472     Medline TA:  Cell Stem Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  730-43     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Astrocytes / metabolism
Cell Proliferation
Male
Mice
Mice, Inbred C57BL
Neural Stem Cells / metabolism*
Phenotype
Receptor, EphB2 / metabolism*
Receptors, Notch / metabolism
Signal Transduction*
Stem Cell Niche / cytology*,  metabolism
Grant Support
ID/Acronym/Agency:
R01 MH066332/MH/NIMH NIH HHS; R01 MH066332/MH/NIMH NIH HHS; R01 MH066332-09/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Notch; EC 2.7.10.1/Receptor, EphB2
Comments/Corrections
Comment In:
Cell Stem Cell. 2010 Dec 3;7(6):647-8   [PMID:  21112558 ]

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