Document Detail

Eph family receptors and their ligands distribute in opposing gradients in the developing mouse retina.
MedLine Citation:
PMID:  8954746     Owner:  NLM     Status:  MEDLINE    
The Eph family of receptor tyrosine kinases and their ligands can be divided into two specificity subclasses: the Eck-related receptors and their GPI-anchored ligands, and the Elk-related receptors and their transmembrane ligands. Previous reports demonstrated that Eck- and Elk-related receptors in the retina distribute in high temporal-low nasal and high ventral-low dorsal gradients, respectively. While others have focused on complementary ligand gradients in the retinal axon target, the tectum, we report that ligands from each subclass also distribute in gradients opposing those of their corresponding receptors within the retina itself. Moreover, ligand gradients in the retina precede ganglion cell genesis. These results support an intraretinal role for Eph family members in addition to their previously proposed role in the development of retinotectal topography. The distinct distributions of Eph family members suggest that each subclass specifies positional information along independent retinal axes.
R C Marcus; N W Gale; M E Morrison; C A Mason; G D Yancopoulos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental biology     Volume:  180     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-01-21     Completed Date:  1997-01-21     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  786-9     Citation Subset:  IM    
Department of Pathology, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, 630 W. 168th Street, New York, New York, 10032, USA.
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MeSH Terms
Cell Membrane / physiology
DNA Probes
Embryonic and Fetal Development
Gene Expression Regulation, Developmental*
Glycosylphosphatidylinositols / metabolism
Mice, Inbred C57BL
Protein Biosynthesis*
Proteins / analysis
Receptor Protein-Tyrosine Kinases / analysis,  biosynthesis*
Retina / cytology,  embryology*,  metabolism
Retinal Ganglion Cells / cytology,  physiology
Reg. No./Substance:
0/DNA Probes; 0/Ephrin-A2; 0/Glycosylphosphatidylinositols; 0/Ligands; 0/Proteins; EC Protein-Tyrosine Kinases

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