Document Detail

Ependymoma: results, prognostic factors and treatment recommendations.
MedLine Citation:
PMID:  9531369     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To review the University of Florida experience in treating ependymomas, analyze prognostic factors, and provide treatment recommendations. METHODS AND MATERIALS: Forty-one patients with ependymoma and no metastases outside the central nervous system received postoperative radiotherapy with curative intent between 1966 and 1989. Ten patients had supratentorial lesions, 22 had infratentorial lesions, and 9 had spinal cord lesions. All patients had surgery (stereotactic biopsy, subtotal resection, or gross total resection). Most patients with high-grade lesions received radiotherapy to the craniospinal axis. Low-grade intracranial lesions received more limited treatment. Spinal cord lesions were treated using either partial spine or whole spine fields. RESULTS: Of 32 intracranial tumors, 21 recurred, all at the primary site; no spinal cord tumors recurred. Overall 10-year survival rates were 51% (absolute) and 46% (relapse-free); by tumor site: spinal cord, 100%; infratentorial, 45%; supratentorial, 20% (p = 0.002). On multivariate analysis, tumor site was the only factor that influenced absolute survival (p = 0.0004); other factors evaluated included grade, gender, age, duration of symptoms, resection extent, primary tumor dose, treatment field extent, surgery-to-radiotherapy interval, and days under radiotherapy treatment. CONCLUSIONS: Patients with supratentorial or infratentorial tumors receive irradiation, regardless of grade. Craniospinal-axis fields are used when spinal seeding is radiographically or pathologically evident. Spinal cord tumors are treated using localized fields to the primary site if not completely resected. Failure to control disease at the primary site remains the main impediment to cure.
M P McLaughlin; R B Marcus; J M Buatti; W M McCollough; J P Mickle; A Kedar; B L Maria; R R Million
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of radiation oncology, biology, physics     Volume:  40     ISSN:  0360-3016     ISO Abbreviation:  Int. J. Radiat. Oncol. Biol. Phys.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-04-08     Completed Date:  1998-04-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7603616     Medline TA:  Int J Radiat Oncol Biol Phys     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  845-50     Citation Subset:  IM    
Department of Radiation Oncology, University of Florida College of Medicine, Gainesville 32610-0385, USA.
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MeSH Terms
Analysis of Variance
Ependymoma / mortality,  radiotherapy*
Infratentorial Neoplasms / mortality,  radiotherapy*
Neoplasm Recurrence, Local
Radiotherapy / adverse effects
Spinal Cord Neoplasms / mortality,  radiotherapy*
Supratentorial Neoplasms / mortality,  radiotherapy*
Survival Rate

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