Document Detail


Eotaxin-3 and interleukin-5 pleural fluid levels are associated with pleural fluid eosinophilia in post-coronary artery bypass grafting pleural effusions.
MedLine Citation:
PMID:  15947325     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The primary aim of this study was to examine the association between pleural fluid (PF) eosinophilia, and the PF and serum levels of interleukin (IL)-5, eotaxin-2, eotaxin-3, and vascular cell adhesion molecule (VCAM)-1 in patients with post-coronary artery bypass grafting (CABG) pleural effusions. DESIGN: A prospective observational study. SETTING: A tertiary teaching hospital. PATIENTS AND METHODS: Thirty-eight patients with post-CABG pleural effusions were recruited into the study. An effusion that contained at least 10% eosinophils was called "eosinophilic." The PF and serum levels of the cytokines and VCAM-1 were measured using an enzyme-linked immunosorbent assay. RESULTS: (1) The number of PF eosinophils significantly correlated with the number of blood eosinophils. (2) PF IL-5 levels were significantly higher than the corresponding serum levels, and there was a significant correlation between the PF and serum IL-5 levels. PF IL-5 levels significantly correlated with the PF eosinophil count, and serum IL-5 levels significantly correlated with the number of blood eosinophils. (3) PF eotaxin-3 levels were significantly higher than serum levels, and PF eotaxin-3 levels significantly correlated with the PF eosinophil count. (4) PF VCAM-1 levels were significantly lower than the corresponding serum levels, and PF VCAM-1 levels were significantly higher in eosinophilic pleural effusions (EPEs) than in non-EPEs. CONCLUSION: In patients with post-CABG pleural effusions, IL-5 and eotaxin-3 are produced preferentially in the pleural cavity, and they are strongly associated with PF eosinophilia.
Authors:
Ioannis Kalomenidis; Georgios T Stathopoulos; Randal Barnette; Yubiao Guo; R Stokes Peebles; Timothy S Blackwell; Richard W Light
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chest     Volume:  127     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-10     Completed Date:  2005-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2094-100     Citation Subset:  AIM; IM    
Affiliation:
Department of Critical Care and Pulmonary Services, Athens Medical School, Evangelismos Hospital, 45-47 Ipsilandou Str, 10675 Athens, Greece. jkalomenidis@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / analysis
Chemokines, CC / analysis*
Cohort Studies
Coronary Artery Bypass / adverse effects*,  methods
Coronary Disease / diagnosis,  surgery
Eosinophilia / diagnosis*
Female
Graft Rejection
Graft Survival
Humans
Interleukin-5 / analysis*
Male
Pleural Effusion / cytology,  metabolism*
Postoperative Complications / diagnosis*
Probability
Prognosis
Prospective Studies
Risk Assessment
Sensitivity and Specificity
Statistics, Nonparametric
Chemical
Reg. No./Substance:
0/Biological Markers; 0/CCL26 protein, human; 0/Chemokines, CC; 0/Interleukin-5

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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