| Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis. | |
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MedLine Citation:
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PMID: 15221302 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare in-season eotaxin-1 levels in tears of patients suffering from seasonal allergic conjunctivitis (SAC) with (1) tears of normal subjects and (2) tears of SAC patients out of season. METHODS: Tears of 11 SAC patients and six control volunteers were collected during the pollen season. Tears of five SAC patients showing a strong sensitivity to grass pollen (skin-prick tests and specific serum IgE) were collected both in season and out of season. ELISA measured eotaxin-1 level. RESULTS: Eotaxin-1 concentration in tears of SAC patients [2,100+/-503 (SEM) pg/ml] and normal subjects (1,193+/-176 pg/ml) were significantly different (P=0.0049). Regarding allergic patients, the clinical score (sum of five allergic criteria) was significantly different in season and out of season (P=0.0043) as was also the case with eotaxin-1 concentration (P=0.024). CONCLUSIONS: The eotaxin-1 concentration in tears of patients showing hay fever could confirm a diagnosis of seasonal ocular allergy. |
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Authors:
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Simone Eperon; Alain Sauty; René Lanz; Annette Leimgruber; Floriana Lurati; Yan Guex-Crosier |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2004-06-25 |
Journal Detail:
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Title: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Volume: 242 ISSN: 0721-832X ISO Abbreviation: Graefes Arch. Clin. Exp. Ophthalmol. Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-11-26 Completed Date: 2005-02-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8205248 Medline TA: Graefes Arch Clin Exp Ophthalmol Country: Germany |
Other Details:
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Languages: eng Pagination: 966-70 Citation Subset: IM |
Affiliation:
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Ocular Immunology, Jules Gonin Eye Hospital, Av. De France 15, 1000, Lausanne 7, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chemokine CCL11 Chemokines, CC / metabolism* Chemotactic Factors, Eosinophil / metabolism* Conjunctivitis, Allergic / metabolism* Enzyme-Linked Immunosorbent Assay Female Humans Male Prospective Studies Seasons Tears / metabolism* Up-Regulation |
| Chemical | |
Reg. No./Substance:
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0/CCL11 protein, human; 0/Chemokine CCL11; 0/Chemokines, CC; 0/Chemotactic Factors, Eosinophil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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