Document Detail

Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis.
MedLine Citation:
PMID:  15221302     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare in-season eotaxin-1 levels in tears of patients suffering from seasonal allergic conjunctivitis (SAC) with (1) tears of normal subjects and (2) tears of SAC patients out of season. METHODS: Tears of 11 SAC patients and six control volunteers were collected during the pollen season. Tears of five SAC patients showing a strong sensitivity to grass pollen (skin-prick tests and specific serum IgE) were collected both in season and out of season. ELISA measured eotaxin-1 level. RESULTS: Eotaxin-1 concentration in tears of SAC patients [2,100+/-503 (SEM) pg/ml] and normal subjects (1,193+/-176 pg/ml) were significantly different (P=0.0049). Regarding allergic patients, the clinical score (sum of five allergic criteria) was significantly different in season and out of season (P=0.0043) as was also the case with eotaxin-1 concentration (P=0.024). CONCLUSIONS: The eotaxin-1 concentration in tears of patients showing hay fever could confirm a diagnosis of seasonal ocular allergy.
Simone Eperon; Alain Sauty; René Lanz; Annette Leimgruber; Floriana Lurati; Yan Guex-Crosier
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-06-25
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  242     ISSN:  0721-832X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-26     Completed Date:  2005-02-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  966-70     Citation Subset:  IM    
Ocular Immunology, Jules Gonin Eye Hospital, Av. De France 15, 1000, Lausanne 7, Switzerland.
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MeSH Terms
Chemokine CCL11
Chemokines, CC / metabolism*
Chemotactic Factors, Eosinophil / metabolism*
Conjunctivitis, Allergic / metabolism*
Enzyme-Linked Immunosorbent Assay
Prospective Studies
Tears / metabolism*
Reg. No./Substance:
0/CCL11 protein, human; 0/Chemokine CCL11; 0/Chemokines, CC; 0/Chemotactic Factors, Eosinophil

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