Document Detail

Eosinophils promote resolution of acute peritonitis by producing proresolving mediators in mice.
MedLine Citation:
PMID:  20959515     Owner:  NLM     Status:  MEDLINE    
Acute inflammation in healthy individuals is self-limiting and has an active termination program. The mechanisms by which acute inflammation is resolved are of interest. In murine zymosan-induced peritonitis, we found that eosinophils are recruited to the inflamed loci during the resolution phase of acute inflammation. In vivo depletion of eosinophils caused a resolution deficit, namely impaired lymphatic drainage with reduced appearance of phagocytes carrying engulfed zymosan in the draining lymph node, and sustained numbers of polymorphonuclear leukocytes in inflamed tissues. Liquid chromatography-tandem mass spectrometry-based lipidomics of the resolving exudates revealed that locally activated eosinophils in the resolution phase produced proresolving mediators, including protectin D1 (PD1) from docosahexaenoic acid. The resolution deficit caused by eosinophil depletion was rescued by eosinophil restoration or the administration of PD1. Eosinophils deficient in 12/15-lipoxygenase could not rescue the resolution phenotype. The present results indicate that mouse eosinophils and eosinophil-derived lipid mediators, including PD1, have a role in promoting the resolution of acute inflammation, expanding the roles of eosinophils in host defense and resolution.
Tomohiro Yamada; Yukako Tani; Hiroki Nakanishi; Ryo Taguchi; Makoto Arita; Hiroyuki Arai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-19
Journal Detail:
Title:  FASEB journal : official publication of the Federation of American Societies for Experimental Biology     Volume:  25     ISSN:  1530-6860     ISO Abbreviation:  FASEB J.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-01     Completed Date:  2011-04-04     Revised Date:  2013-05-13    
Medline Journal Info:
Nlm Unique ID:  8804484     Medline TA:  FASEB J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  561-8     Citation Subset:  IM    
Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
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MeSH Terms
Arachidonate 12-Lipoxygenase
Arachidonate 15-Lipoxygenase
Docosahexaenoic Acids / metabolism
Eosinophils / physiology*
Inflammation / metabolism
Mice, Inbred C57BL
Peritonitis / chemically induced,  metabolism*
Time Factors
Zymosan / toxicity
Reg. No./Substance:
0/12-15-lipoxygenase; 0/protectin D1; 25167-62-8/Docosahexaenoic Acids; 9010-72-4/Zymosan; EC 12-Lipoxygenase; EC 15-Lipoxygenase

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