Document Detail

Eosinophils play a major role in the severity of exercise-induced bronchoconstriction in children with asthma.
MedLine Citation:
PMID:  17048254     Owner:  NLM     Status:  MEDLINE    
Exercise-induced bronchoconstriction (EIB) was associated with eosinophilic airway inflammation, bronchial hyperresponsiveness (BHR), atopy and airway obstruction. To understand the pathogenesis of EIB, we determine whether eosinophil is more related to the mechanism of EIB than atopy, BHR and airway obstruction. This study comprised 268 asthmatic children who underwent lung function test, methacholine challenge test, exercise challenge test, and blood tests for total IgE levels and total eosinophil counts (TEC). Urine eosinophil protein X (EPX) levels after exercise were measured by using ELISA method. EIB was observed in 195 of 268 asthmatics (72.8%). Asthmatics with EIB showed significantly increased TEC (P < 0.01) and decreased log PC(20) as compared with asthmatics without EIB. Maximal percent fall in FEV(1) after exercise was significantly correlated with TEC, log IgE, FEF(25-75%), log PC(20) (P < 0.001, respectively) and FEV(1) (P = 0.013). When the same study was carried out in nonatopic asthmatics, those with EIB showed significantly increased TEC (P = 0.01) compared with those without EIB; however, log PC(20), FEV(1), and FEF(25-75%) showed no significant differences between the two groups of nonatopic asthmatics. In addition, there was a significant correlation between the severity of EIB and TEC in nonatopic asthmatics. Urine EPX/Cr levels after exercise were correlated with the severity of EIB (r = 0.238, P = 0.014). Blood eosinophils and urine EPX/Cr after exercise correlate significantly with the maximal percent fall in FEV(1) after exercise, therefore EIB may reflect a state of eosinophilic inflammation in the airway of asthmatic children.
So-Yeon Lee; Hyo-Bin Kim; Ja-Hyung Kim; Bong-Seong Kim; Mi-Jin Kang; Seong-Ok Jang; Soo-Jong Hong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  41     ISSN:  8755-6863     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-02     Completed Date:  2007-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1161-6     Citation Subset:  IM    
Department of Pediatrics, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
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MeSH Terms
Asthma, Exercise-Induced / metabolism,  pathology*,  physiopathology
Bronchoconstriction / physiology*
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Eosinophil-Derived Neurotoxin / urine
Eosinophils / metabolism,  pathology*
Forced Expiratory Volume / physiology
Immunoglobulin E / blood
Leukocyte Count
Severity of Illness Index
Reg. No./Substance:
37341-29-0/Immunoglobulin E; EC 3.1.-/Eosinophil-Derived Neurotoxin

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