| Eosinophils in innate immunity: an evolving story. | |
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MedLine Citation:
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PMID: 21042920 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eosinophils are innate immune leukocytes found in relatively low numbers within the blood. Terminal effector functions of eosinophils, deriving from their capacity to release their content of tissue-destructive cationic proteins, have historically been considered primary effector mechanisms against specific parasites, and are likewise implicated in tissue damage accompanying allergic responses such as asthma. However, the past decade has seen dramatic advancements in the field of eosinophil immunobiology, revealing eosinophils to also be key participants in many other facets of innate immunity, from bridging innate and adaptive immune responses to orchestrating tissue remodeling events. Here, we review the multifaceted functions of eosinophils in innate immunity that are currently known, and discuss new avenues in this evolving story. |
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Authors:
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Revital Shamri; Jason J Xenakis; Lisa A Spencer |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-11-03 |
Journal Detail:
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Title: Cell and tissue research Volume: 343 ISSN: 1432-0878 ISO Abbreviation: Cell Tissue Res. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-04 Completed Date: 2011-04-06 Revised Date: 2013-06-13 |
Medline Journal Info:
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Nlm Unique ID: 0417625 Medline TA: Cell Tissue Res Country: Germany |
Other Details:
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Languages: eng Pagination: 57-83 Citation Subset: IM |
Affiliation:
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Division of Allergy and Inflammation, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Eosinophils / immunology* Health Humans Immunity, Innate / immunology* Receptors, Immunologic / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HL095699/HL/NHLBI NIH HHS; R01 HL095699-02/HL/NHLBI NIH HHS; R01 HL095699-03/HL/NHLBI NIH HHS; R37 AI020241/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Immunologic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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