Document Detail


Eosinophils in innate immunity: an evolving story.
MedLine Citation:
PMID:  21042920     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eosinophils are innate immune leukocytes found in relatively low numbers within the blood. Terminal effector functions of eosinophils, deriving from their capacity to release their content of tissue-destructive cationic proteins, have historically been considered primary effector mechanisms against specific parasites, and are likewise implicated in tissue damage accompanying allergic responses such as asthma. However, the past decade has seen dramatic advancements in the field of eosinophil immunobiology, revealing eosinophils to also be key participants in many other facets of innate immunity, from bridging innate and adaptive immune responses to orchestrating tissue remodeling events. Here, we review the multifaceted functions of eosinophils in innate immunity that are currently known, and discuss new avenues in this evolving story.
Authors:
Revital Shamri; Jason J Xenakis; Lisa A Spencer
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-11-03
Journal Detail:
Title:  Cell and tissue research     Volume:  343     ISSN:  1432-0878     ISO Abbreviation:  Cell Tissue Res.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-04     Completed Date:  2011-04-06     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0417625     Medline TA:  Cell Tissue Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  57-83     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease
Eosinophils / immunology*
Health
Humans
Immunity, Innate / immunology*
Receptors, Immunologic / metabolism
Grant Support
ID/Acronym/Agency:
HL095699/HL/NHLBI NIH HHS; R01 HL095699/HL/NHLBI NIH HHS; R37 AI020241/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Immunologic
Comments/Corrections

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